Monoclonal antibody | |
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Type | Whole antibody |
Source | Humanized |
Target | IL6 |
Clinical data | |
Other names | ALD518, BMS-945429 |
Routes of administration | infusion |
ATC code |
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Legal status | |
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Identifiers | |
CAS Number | |
ChemSpider |
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UNII | |
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Chemical and physical data | |
Formula | C6426H9972N1724O2032S42 |
Molar mass | 145239.02 g·mol−1 |
Clazakizumab (formerly ALD518 and BMS-945429), an investigational drug, is an aglycosylated, humanized rabbit monoclonal antibody against interleukin-6. [1] Clazakizumab was developed by Bristol Myers Squib and Alder Biopharmaceuticals. A preliminary randomized, double-blind, placebo-controlled, phase 2 dose-ranging study of clazakizumab in psoriatic arthritis patients, funded by the manufacturer, suggested that clazakizumab may be an effective treatment option for musculoskeletal aspects of psoriatic arthritis; however, the antibody lacked a dose-response effect. [2]