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Class of enzymes
All-trans-retinol 13,14-reductase Identifiers
Aliases (13,14)-all-trans-retinol saturaseRetSatall-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductaseall-trans-retinol:all-trans-13,14-dihydroretinol saturaseretinol saturaseExternal IDs
GeneCards :
[1] ;
OMA :
- orthologs
Wikidata
In
enzymology , an all-trans-retinol 13,14-reductase (
EC
1.3.99.23 ) is an
enzyme , encoded by the RETSAT gene,
[1]
[2]
[3] that
catalyzes the
chemical reaction
all-trans-13,14-dihydroretinol + acceptor
⇌
{\displaystyle \rightleftharpoons }
all-trans-retinol + reduced acceptor
Thus, the two
substrates of this enzyme are
all-trans-13,14-dihydroretinol and
acceptor , whereas its two
products are
all-trans-retinol and
reduced acceptor . Under physiological conditions the reaction proceeds in the opposite direction catalyzing the saturation of the 13-14 double bond of
all-trans-retinol .
This enzyme belongs to the family of
oxidoreductases , specifically those acting on the CH-CH group of donor with other acceptors. The
systematic name of this enzyme class is all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase . Other names in common use include retinol saturase , RetSat , (13,14)-all-trans-retinol saturase , and all-trans-retinol:all-trans-13,14-dihydroretinol saturase .
The gene has also been called PPAR-alpha-regulated and starvation-induced gene protein.
[4]
References
^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
^ Moise AR, Kuksa V, Imanishi Y, Palczewski K (Nov 2004).
"Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase*" . J Biol Chem . 279 (48): 50230–42.
doi :
10.1074/jbc.M409130200 .
PMC
2665716 .
PMID
15358783 .
^
"Entrez Gene: RETSAT retinol saturase (all-trans-retinol 13,14-reductase)" .
^
"RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene & protein" . www.uniprot.org . Retrieved 2017-11-05 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Hillier LW, Graves TA, Fulton RS, et al. (2005).
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31.
Bibcode :
2005Natur.434..724H .
doi :
10.1038/nature03466 .
PMID
15815621 .
Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26.
doi :
10.1093/dnares/12.2.117 .
PMID
16303743 .
Activity Regulation Classification Kinetics Types