Adenylyl cyclase type 7 is an
enzyme that in humans is encoded by the ADCY7gene.[5][6]
Function
This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of
cyclic AMP from
ATP and is inhibitable by
calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hellevuo K, Berry R, Sikela JM, Tabakoff B (Mar 1995). "Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16". Hum Genet. 95 (2): 197–200.
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Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997). "Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism". Am. J. Med. Genet. 74 (1): 95–8.
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Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46.
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Yan SZ, Tang WJ (2002). "Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase". G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology. Vol. 345. pp. 231–41.
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10.1016/S0076-6879(02)45019-7.
ISBN978-0-12-182246-0.
PMID11665607.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110.
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PMID12503609.
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