From Wikipedia, the free encyclopedia
Class of enzymes
3-ketosteroid 9alpha-monooxygenase (
EC
1.14.13.142, KshAB, 3-ketosteroid 9alpha-hydroxylase) is an
enzyme with
systematic name androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9alpha-hydroxylating).
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
- androsta-1,4-diene-3,17-dione + NADH + H+ + O2 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O
3-Ketosteroid 9alpha-monooxygenase is involved in the
cholesterol degradation in several
bacterial pathogens.
References
-
^ Petrusma M, Dijkhuizen L, van der Geize R (August 2009).
"Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity". Applied and Environmental Microbiology. 75 (16): 5300–7.
Bibcode:
2009ApEnM..75.5300P.
doi:
10.1128/AEM.00066-09.
PMC
2725467.
PMID
19561185.
-
^ Capyk JK, D'Angelo I, Strynadka NC, Eltis LD (April 2009).
"Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis". The Journal of Biological Chemistry. 284 (15): 9937–46.
doi:
10.1074/jbc.M900719200.
PMC
2665117.
PMID
19234303.
-
^ Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD (November 2011).
"Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis". The Journal of Biological Chemistry. 286 (47): 40717–24.
doi:
10.1074/jbc.M111.289975.
PMC
3220451.
PMID
21987574.
External links
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