The 1954 United States Senate elections in Wyoming took place on November 2, 1954. Incumbent Democratic Senator
Lester C. Hunt, who decided not to be a candidate for re-election, committed suicide by firearm on June 19, 1954, and Republican Governor
Clifford J. Rogers appointed former state highway commissioner
Edward D. Crippa to replace him. Two elections for the Senate seat were held on the same day; one as a special election to fill the remainder of Hunt's original six-year term, and another to select a Senator to serve the next six-year term. Senator Crippa did not run for re-election.
Crippa did not run for re-election; instead, Congressman
William Henry Harrison III won a contested Republican primary and advanced to the general election, where he faced former Senator
Joseph C. O'Mahoney, the Democratic nominee. In the midst of a largely neutral political environment—Democrats gained a handful of seats in Congress
nationwide, which enabled them to flip the Senate, while Republican
Milward Simpson narrowly won the
gubernatorial election—O'Mahoney narrowly defeated Harrison to return to the Senate.
As of 2023, this is the last time Democrats won Wyoming's Class 2 Senate seat.