From Wikipedia, the free encyclopedia
Trichosanthin is a
ribosome-inactivating protein .
[1]
[2] It is derived from
Trichosanthes kirilowii .
[3] It is also an
abortifacient .
[4]
References
^ Too PH, Ma MK, Mak AN, et al. (February 2009).
"The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome" . Nucleic Acids Res . 37 (2): 602–10.
doi :
10.1093/nar/gkn922 .
PMC
2632931 .
PMID
19073700 .
^ Shaw PC, Lee KM, Wong KB (May 2005). "Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties". Toxicon . 45 (6): 683–9.
doi :
10.1016/j.toxicon.2004.12.024 .
PMID
15804517 .
^ Zhao J, Ben LH, Wu YL, et al. (July 1999).
"Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors" . J. Exp. Med . 190 (1): 101–11.
doi :
10.1084/jem.190.1.101 .
PMC
2195565 .
PMID
10429674 .
^ Li MX, Yeung HW, Pan LP,
Chan SI (November 1991).
"Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro" . Nucleic Acids Res . 19 (22): 6309–12.
doi :
10.1093/nar/19.22.6309 .
PMC
329144 .
PMID
1659689 .
External links