SR 151 begins in
Macon County at an intersection with
SR 56 in downtown
Red Boiling Springs. It goes southeastward as E Main Street to leave the town and have an interchange with
SR 52.[1] It continues southeast through farmland to cross into the southwestern corner of
Clay County for a short distance before crossing into the mountains of
Jackson County.[2] SR 151 continues southeastward through the mountains along a narrow valley before entering
North Springs and coming to an end at an intersection with SR 56.[3] The entire route of SR 151 is a rural two-lane highway.[4]