Clinical data | |
---|---|
Trade names | Lymphoseek |
Other names | technetium Tc 99m tilmanocept |
AHFS/ Drugs.com | Micromedex Detailed Consumer Information |
License data |
|
Pregnancy category |
|
Routes of administration | Intradermal, subcutaneous, intratumor |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Elimination half-life | 1.75 to 3.05 hours at injection site |
Identifiers | |
| |
CAS Number | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | (C6H10O5)n(C19H28N4O9S99mTc)3–8(C13H24N2O5S2)12–20(C5H11NS)0–17 |
Molar mass | 15,281–23,454 g/mol [4] |
Technetium (99mTc) tilmanocept, sold under the brand name Lymphoseek, is a radiopharmaceutical diagnostic imaging agent used to locate lymph nodes which may be draining from tumors, and assist doctors in locating lymph nodes for removal during surgery. [6]
The most common side effects include pain or irritation at the injection site. [7]
It was approved for medical use in the United States in March 2013, [4] [7] and in the European Union in November 2014. [5]
In the US, technetium (99mTc) tilmanocept is indicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in people with solid tumors for which this procedure is a component of intraoperative management; and guiding sentinel lymph node biopsy using a handheld gamma counter in people with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma. [4] [7]
In the EU, technetium (99mTc) tilmanocept is indicated for imaging and intraoperative detection of sentinel lymph nodes draining a primary tumor in adults with breast cancer, melanoma, or localized squamous cell carcinoma of the oral cavity. [5] External imaging and intraoperative evaluation may be performed using a gamma detection device. [5]
The safety and effectiveness of technetium (99mTc) tilmanocept were established in two clinical trials of 332 participants with melanoma or breast cancer. [7] All participants were injected with technetium (99mTc) tilmanocept and blue dye, another drug used to help locate lymph nodes. [7]