From Wikipedia, the free encyclopedia
Mouse monoclonal antibody
Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a
mouse
monoclonal antibody derivative used in the diagnosis of
lung cancer,
[1]
gastrointestinal,
breast,
ovary,
pancreas,
kidney,
cervix, and
bladder carcinoma.
[2] The antibody part,
nofetumomab, is attached to the
chelator
merpentan, which
links it to the
radioisotope
technetium-99m (99mTc).
[3]
Nofetumomab
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen
EpCAM.
[4] and/or
CD20/
MS4A1
[5]
It is the
Fab part of murine MAb
NR-LU-10.
[6]
Merpentan
The chelator part : merpentan is a
phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.
[6]
Phenthioate
Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate
[7]
References
-
^ Straka MR, Joyce JM, Myers DT (January 2000). "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical Nuclear Medicine. 25 (1): 54–5.
doi:
10.1097/00003072-200001000-00013.
PMID
10634533.
-
^ Breitz HB, Tyler A, Bjorn MJ, Lesley T, Weiden PL (September 1997). "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical Nuclear Medicine. 22 (9): 615–20.
doi:
10.1097/00003072-199709000-00007.
PMID
9298295.
-
^
"International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Geneva: World Health Organization. 2002. Archived from
the original (PDF) on July 3, 2011.
-
^ Tsurushita N, Vasquez M (January 2004).
"Humanization of monoclonal antibodies". In Reth M, Radbruch A, Alt F, Honjo T, Neuberger M (eds.). Molecular Biology of B Cells. Academic Press. pp. 533–545.
ISBN
978-0-08-047950-7.
-
^
"Anti-MS4A1 Therapeutic Antibody (Technetium (99MTC) Nofetumomab Merpentan)". Creative BioLabs.
- ^
a
b Mudd E (27 February 2015).
"Monoclonal Antibody Radionuclide Test Kits". Pharmacological Sciences.
-
^
US 3934010, Drabek J, Varsanyi D, "Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters", issued 20 January 1976, assigned to Ciba Geigy Corporation