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Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 18:55, 16 January 2022 (UTC)
Yet more confusion! "Dale, Ritter and Rang: Pharmacology 5th Ed", pretty much *the* standard undergrad text on pharmacology gives the P as designating "Pink" as 450nm light is of a pink hue. However, P for "pigment" sounds more believable when you consider that the "P number" for chlorophylls (related to the haems of the P450s) stands for "Pigment absorbing at...". Possibily we should give all the alternative meanings and state that there is some ambiguity? Duke Of Earl 14:30, 3 March 2006 (UTC)
From the reference reading listed (Nelson D.), it says the 'P' of Cytochrome P450 comes from 'pigment' but not 'peak'. Minor, though it may seem, should it be edited?
I want to know more . How come this article has no references/further reading? How can I trust it? 67.113.3.148 03:00, 5 May 2005 (UTC)
If I knew the answer, I would. This is a request for more info from those who know. Like a reference into the literature is something I like, and something all articles should have, in my opinion. 67.124.100.215 07:33, 9 May 2005 (UTC)
"The Human Genome Project has identified 63 human genes coding for the various cytochrome P450 enzymes." Well, what are they? Some are listed, what are the rest? 67.124.100.215 07:33, 9 May 2005 (UTC)
I think listing the human CYPs individually (eg separate lines for CYP1A1, CYP1A2, CYP1B1, etc) is not necessarily the best way of presenting them. There are not (and will not likely be) individual pages for each CYP. More to the point, it is sometimes impossible to assign individual functionality to each CYP - they tend to have overlapping specificity. I'm not sure an arragement that gives such an 'outline' of the CYPs is the correct way to go. In addition, the numbers from the family and subfamily are confusing enough, especially since a simple list gets out of sync with the names. Comments? Jed 03:45, 6 March 2006 (UTC)
Although I have no text books available to confirm this, my lecturer (and my lecture notes) seem to suggest there are in fact 21 families?
There are a great many more than 21 CYP families. At last count (Oct 2006) there were 6422 known sequences in 708 families (99 in animals). Jed 21:43, 14 November 2006 (UTC)
This page needs serious work in order to remove some plain falsities and add valuable information that is now known about the enzyme family. I'll work on this article after I finish my thesis...on computational study of P450s. ju66l3r 20:00, 9 November 2006 (UTC)
Hopefully not that much that is plainly false. Plenty of info to add - to the extent that it might be useful to keep a summary paragraph/section at the top.... Jed 21:44, 14 November 2006 (UTC)
I'm trying to keep the nomenclature consitent, with the official name (CYP#letter#) first and the common name following in parentheses. As the sequences proliferate it becomes useful to try to keep the nomenclature consistent. Contact David Nelson, the P450 nomenclature guy, if you have comments on the specifics of the nomenclature. Jed 21:53, 14 November 2006 (UTC)
Colleagues, does anybody know why on earth this article is titled "Cytochrome P450 oxidase"? The widely accepted, if not quite correct, name of this superfamily is "cytochrome P450" (CYP for short); many people nowadays prefer to call it simply "P450" (in contrast to cytochromes, which are purely electron-transfer proteins, P450s are enzymes). It seems that this article started as "P450", then was renamed "Cytochrome P450 oxidase". It is unfortunate name, since (by analogy with cytochrome c oxidase) one can think this is the enzyme that... oxidizes cytochrome P450! Moreover, "oxidase" cannot be applied to all P450s since some of them are not classified as oxidoreductases at all. (See P450-containing systems). I suggest renaming this article back to "P450". Metalloid 01:10, 9 February 2007 (UTC)
I concur that Cytochrome P450 is the preferred title/enzyme name. I believe this is the overall name preferred by the Cytochrome P450 nomenclature committee. Jed 02:28, 13 February 2007 (UTC)
I don't think that the "main" reaction carried out by P450's should be listed in the introductory paragraph. Many important reactions carried out do not have that stoichiometry, and while it's perhaps useful to have it listed, I feel that it should be further down the page. I'm commenting here rather than making the edits to gather opinions. Jed 15:05, 26 February 2007 (UTC)
Please keep it as technical as it is now. Thanks. —Preceding unsigned comment added by 201.220.15.68 ( talk) 19:28, 17 July 2010 (UTC)
Hello, please could this part be clarified? "Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen)." I don't understand the part in brackets and think it could be clearer. I am currently using wikipedia to learn about iron/oxygen/enzymatic reactions. I'm also trying to work out the difference between a hydroxylation reaction and a monooxygenase reaction, in particular with regards to CYP 450 and I don't think this is clear from the various enzyme family pages. Thank you.
KStar777 (
talk) 12:05, 15 June 2017 (UTC)
E.g. elsewhere I have read that CYP 450 is "characterized as a class of proteins with activity as a monooxygenase involved in hydroxylation associated with electron transfer" Thank you. http://www.chem.qmul.ac.uk/iubmb/etp/etp4.html KStar777 ( talk) 10:30, 16 June 2017 (UTC)
I feel that P450-containing_systems should be merged in to the main P450 page. If each eletron transfer protein were to have its own page with mention of CYPs and a link that would be fine, but it doesn't make sense to separate out the information on CYP electron transport. Jed 15:05, 26 February 2007 (UTC)
There are quite a number of human P450 families listed here that aren't mentioned by the Human Cytochrome P450 (CYP) Allele Nomenclature Committee. Are they just listing the ones with known polymorphisms?
This is even more confusing in the light of Dr Nelson's count, which differs from both ours and the Committee's (for example, we don't list 2B7 as a pseudogene, and in fact seem to be pretty spotty in our coverage of pseudogenes, and Dr. Nelson doesn't list 2C11, 2U or 2W at all, among others.).
Of course, Dr. Nelson's page seems to be about 7 years old, so that could account for some of the discrepancies.-- Slashme 21:23, 4 March 2007 (UTC)
The intro says "found in bacteria, archaea and eukaryotes". That is all three domains of life (excluding viruses). This says that CYPs are found generally in all forms of life; are they found specifically in all known species? That would allow the introduction 71.41.210.146 18:37, 23 June 2007 (UTC)
Placing this here just in case that something is missing in the article. CYP11A1; CYP11B1; CYP11B2; CYP17A1; CYP19A1; CYP1A1; CYP1A2; CYP1B1; CYP20A1; CYP21; CYP21A2; CYP24; CYP24A1; CYP26A1; CYP26B1; CYP26C1; CYP27A1; CYP27B1; CYP27C1; CYP2A13; CYP2A6; CYP2A6V2; CYP2A7; CYP2B; CYP2B6; CYP2C18; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2D7P1; CYP2E1; CYP2F1; CYP2J2; CYP2R1; CYP2S1; CYP2U1; CYP2W1; CYP39A1; CYP3A3; CYP3A4; CYP3A43; CYP3A5; CYP3A7; CYP46A1; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F12; CYP4F2; CYP4F22; CYP4F3; CYP4F8; CYP4V2; CYP4X1; CYP4Z1; CYP4Z2P; CYP51A1; CYP7A1; CYP7B1; CYP8B1; PTGIS; TBXAS1; Biophys ( talk) 03:02, 11 December 2007 (UTC)
With due respect to Biophys, I reverted the 11 December edits, for the following reasons: while many eukaryotic CYPs are membrane bound, a very significant and important fraction is not, and the roles and functions of eukaryotic P450s are far far more than hydrocarbon oxidation. Jed ( talk) 17:41, 8 January 2008 (UTC)
Is anyone familiar with Protein Box Bot? If so, would they be able to insert this in place of the Template:pfam? Jed ( talk) 19:36, 18 March 2008 (UTC)
Hi,
I have put in a diagram that I drew for my thesis (now already published: Not a commercial work, and author's permission granted ;-) and the accompanying description and references. I think this could do with a once-over from the P450 experts here. -- Slashme ( talk) 11:17, 5 July 2008 (UTC)
I have converted the steroidogenic pathway diagram to SVG. Now it needs proofreading. Note that for simplicity, I have only shown the stereochemistry of each functional group the first time that it appears in the diagram. -- Slashme ( talk) 16:28, 3 August 2008 (UTC)
You have a list of stuff that inhibits p450 but what enhances or turns it on? Thanks. Interestedperson ( talk) 00:47, 3 February 2009 (UTC)
The statement that all drugs are detoxified and eventually excreted is inaccurate. The referenced source does not make this statement. One must be careful to avoid gross generalizations. CYP mediated xenobiotic metabolism can result in metabolites of more toxicological potency than the parent compound. Page 73 of the referenced article dicusses this and provides CYP2E1 acetaminophen toxicity as an example. —Preceding
unsigned comment added by
134.154.242.237 (
talk) 20:20, 12 September 2009 (UTC)
Rather than "there is a committee that recommends nomenclature" why not just state INTERNATIONAL UNION OF BIOCHEMISTRY AND MOLECULAR BIOLOGY?
I can't be the only person thinking about this: What the hell is a Cytochrome P450? I got to this article after reading about the starfruit. I wanted to know why those with kidney problems cannot eat starfruit. There it says the starfruit "is considered to be a potent inhibitor of seven cytochrome P450 isoforms. These enzymes are significant in the first pass elimination of many medicines...." I wanted to figure out why and how this "cytochrome P450" inhibits prescription drug interaction.
Then I read the lead paragraph of this article and it's just gibberish. I'm sorry but this article does not seem to obey the rule WP:TECHNICAL. At the very least, the lead paragraph should be more accessible. I have studied college biology some years ago and took two years of chemical engineering (before I switched schools and switched my major of study), so I should be able to understand, in a basic way, what this is. My understanding from this confusing lead-in is that Cytochrome P450 is simply an enzyme found in humans and many other organisms, though I could be wrong. If that is true, then the lead-in should say something like "Cytochrome P450 is a very large and diverse superfamily of enzymes made from hemoproteins..." which is much simpler. Obviously I am no expert though. Midtempo-abg ( talk) 00:55, 1 January 2010 (UTC)
I'm an embedded software engineer, not a biologist, so you can see my mind is open to reading other meanings into what might be basic knowledge to biologists. Clarity is needed. I propose either of two actions:Hmm, what does CYP mean? Cytochrome? Are the CYP450 enzymes just a small part of the 11500 CYP enzymes mentioned in the last paragraph? Are there others, like CYP451, CYP452, etc.?
. 16:29, 17 February 2010 (UTC) —Preceding unsigned comment added by Jedgold ( talk • contribs)
In the mechanism section it's said that the "peroxide shunt" is from the ferrous iron form to the Fe(v) form "compund 1" (the route titled "S" in the picture). But when I got it right from the literature (e.g. in the cited book [8] on page 183) the Fe(v)-form is formed from the ferric iron form through the peroxide shunt mechanism. Does anybody know it excactly and may change this... —Preceding unsigned comment added by 82.82.72.130 ( talk) 15:56, 21 February 2010 (UTC)
Among a few minor grammatical 'enhancements', I changed the statement under Drug metabolism, that read - All drugs are detoxified... to Most drugs undergo biotransformation..., since All is a word you don't want to use in the biological sciences as well as None, Never, Always etc; plus it's just not true: some drugs are excreted unchanged i.e. eliminated. The statement under Drug interaction, that inhibition of the CYP causes accumulation of the drug to toxic levels possibly causing an overdose is inaccurate even from the definition in the overdose article itself. —Preceding unsigned comment added by Edu32 ( talk • contribs) 19:11, 14 April 2010 (UTC)
Why is there no information about CYP119? —Preceding unsigned comment added by 173.180.36.54 ( talk) 05:55, 22 March 2011 (UTC)
the diagram violates conservation of charge in several places. One might also wish to consult Rittle & Green, Science 330 (2010) 933 for newest findings on the reaction mechanism. —Preceding unsigned comment added by 207.42.135.25 ( talk) 20:22, 14 April 2011 (UTC)
Other publications refer to DAF-9 as a cytochrome P450 (found in Caenorhabditis elegans). Should it be mentioned here ? - Rod57 ( talk) 02:21, 22 February 2012 (UTC)
Have any studies been done on P450 disorders? — Preceding unsigned comment added by 99.190.133.143 ( talk) 18:00, 9 April 2012 (UTC)
I just arrived here from the article Unspecific monooxygenase. Unfortunately, that article was difficult for me to understand, but it seems that it may be appropriate to merge it into this article. I hope someone with more expertise than me can attend to this issue. If it is decided not to merge it into this article, it would be great if Unspecific monooxygenase could at least be made slightly more understandable to a non-enzymologist. Onefireuser ( talk) 17:30, 21 May 2013 (UTC)Onefireuser
a lot of bodybuilders take liver tablets. they claim it helps endurance due to the p450, and they cite this study by ershoff:
Proc Soc Exp Biol Med. 1951 Jul;77(3):488-91
'Dr. B. H. Ershoff took three groups of rats and fed them controlled diets for a twelve week period. Group one ate a basic diet fortified with vitamins and minerals. Group two ate as much as they wanted of the same diet plus B vitamins and brewer's yeast. Group three ate the basic diet but had 10% desiccated liver added to their rations.
Then the doctor placed the rats one by one into a drum of water, out of which they could not climb, it was either swim or drown. The group one rats swam an average of 13.2 minutes. Group two, an average of 13.4 minutes. Group three, however, were still swimming at the end of two hours.' — Preceding unsigned comment added by 108.184.252.247 ( talk) 06:36, 25 May 2013 (UTC)
"Hydroxylate estrogen" is not a subfamily. The text is badly garbled. 69.72.92.100 ( talk) 23:21, 21 December 2015 (UTC)
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P450 has many important functions, it has many different genes and it's quite difficult to get a grasp of it at first.
I was very confused about the nomenclature, I had to look further to understand it better.
The InterPro has a good basic explanation.
But what can probably most help is the first article about the evolution of this gene and how they named it:
Some other related articles:
I'm will leave this here so it may be useful for someone. I also may use it later as a reference in the article.
– Arthurfragoso ( talk) 07:07, 26 May 2019 (UTC)
"Too many to list" is found in some table cells when it is blatantly not the case due to things like formatting that could be used. This should be replaced with a list of pseudogenes, which could be collapsed by default if necessary. Anditres ( talk) 23:22, 8 May 2022 (UTC)
The redirect
CYP81A has been listed at
redirects for discussion to determine whether its use and function meets the
redirect guidelines. Readers of this page are welcome to comment on this redirect at
Wikipedia:Redirects for discussion/Log/2023 July 26 § CYP81A until a consensus is reached.
Mdewman6 (
talk) 22:42, 26 July 2023 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 17 January 2024 and 9 March 2024. Further details are available
on the course page. Student editor(s):
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article contribs). Peer reviewers:
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— Assignment last updated by KemiahOwoh ( talk) 19:12, 13 February 2024 (UTC)
This article would benefit from splitting because the topic is massive. There are many hundreds or thousands of P450s. The present article is a magnet for citing comments on each of these specialized derivatives. One idea is to have:
-- Smokefoot ( talk) 15:03, 8 March 2024 (UTC)
Done see
Cytochrome P450 (individual enzymes). Others are welcome to readjust, relabel, modify, etc.--
Smokefoot (
talk) 22:58, 17 May 2024 (UTC)