From Wikipedia, the free encyclopedia
tRNA pseudouridine55 synthase (
EC
5.4.99.25, TruB, aCbf5, Pus4, YNL292w (gene), Psi55 tRNA pseudouridine synthase, tRNA:Psi55-synthase, tRNA pseudouridine 55 synthase, tRNA:pseudouridine-55 synthase, Psi55 synthase, tRNA Psi55 synthase, tRNA:Psi55 synthase, tRNA-uridine55 uracil mutase, Pus10, tRNA-uridine54/55 uracil mutase) is an
enzyme with
systematic name tRNA-uridine55 uracil mutase.
[1]
[2]
[3]
[4]
[5]
[6] This enzyme
catalyses the following
chemical reaction
- tRNA uridine55 tRNA pseudouridine55
Pseudouridine synthase TruB from
Escherichia coli specifically modifies uridine55 in tRNA molecules.
References
-
^ Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J (March 1995).
"Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli". RNA. 1 (1): 102–12.
PMC
1369054.
PMID
7489483.
-
^ Becker HF, Motorin Y, Planta RJ, Grosjean H (November 1997).
"The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs". Nucleic Acids Research. 25 (22): 4493–9.
doi:
10.1093/nar/25.22.4493.
PMC
147073.
PMID
9358157.
-
^ Pieńkowska J, Wrzesiński J, Szweykowska-Kulińska Z (1998).
"A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases". Acta Biochimica Polonica. 45 (3): 745–54.
doi:
10.18388/abp.1998_4268.
PMID
9918501.
-
^ Chaudhuri BN, Chan S, Perry LJ, Yeates TO (June 2004).
"Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft". The Journal of Biological Chemistry. 279 (23): 24585–91.
doi:
10.1074/jbc.m401045200.
PMID
15028724.
-
^ Hoang C, Hamilton CS, Mueller EG, Ferré-D'Amaré AR (August 2005).
"Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain". Protein Science. 14 (8): 2201–6.
doi:
10.1110/ps.051493605.
PMC
2279332.
PMID
15987897.
-
^ Gurha P, Gupta R (December 2008).
"Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA". RNA. 14 (12): 2521–7.
doi:
10.1261/rna.1276508.
PMC
2590954.
PMID
18952823.
External links
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