From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
TERF1-interacting nuclear factor 2 is a
protein that in humans is encoded by the TINF2
gene .
[5]
[6] TINF2 is a component of the
shelterin protein complex found at the end of
telomeres .
[7]
Interactions
TINF2 has been shown to
interact with
ACD ,
[8]
[9]
POT1
[8]
[9]
[10] and
TERF1 .
[5]
[9]
[11]
References
^
a
b
c
ENSG00000284915 GRCh38: Ensembl release 89: ENSG00000092330, ENSG00000284915 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000007589 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Kim SH, Kaminker P, Campisi J (Dec 1999).
"TIN2, a new regulator of telomere length in human cells" . Nature Genetics . 23 (4): 405–12.
doi :
10.1038/70508 .
PMC
4940194 .
PMID
10581025 .
^
"Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2" .
^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008).
"TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita" . American Journal of Human Genetics . 82 (2): 501–9.
doi :
10.1016/j.ajhg.2007.10.004 .
PMC
2427222 .
PMID
18252230 .
^
a
b Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004).
"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex" . Genes & Development . 18 (14): 1649–54.
doi :
10.1101/gad.1215404 .
PMC
478187 .
PMID
15231715 .
^
a
b
c Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology . 6 (7): 673–80.
doi :
10.1038/ncb1142 .
PMID
15181449 .
S2CID
11543383 .
^ Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature . 423 (6943): 1013–8.
Bibcode :
2003Natur.423.1013L .
doi :
10.1038/nature01688 .
PMID
12768206 .
S2CID
4370276 .
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005).
"A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–68.
doi :
10.1016/j.cell.2005.08.029 .
hdl :
11858/00-001M-0000-0010-8592-0 .
PMID
16169070 .
Further reading
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Li B, Oestreich S, de Lange T (May 2000).
"Identification of human Rap1: implications for telomere evolution" . Cell . 101 (5): 471–83.
doi :
10.1016/S0092-8674(00)80858-2 .
PMID
10850490 .
Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG (Feb 2002).
"A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins" . European Journal of Human Genetics . 10 (2): 107–12.
doi :
10.1038/sj.ejhg.5200775 .
PMID
11938440 .
Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N (2003). "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers". Anticancer Research . 22 (6A): 3303–7.
PMID
12530079 .
Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature . 423 (6943): 1013–8.
Bibcode :
2003Natur.423.1013L .
doi :
10.1038/nature01688 .
PMID
12768206 .
S2CID
4370276 .
Kim SH, Han S, You YH, Chen DJ, Campisi J (Jul 2003).
"The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro" . EMBO Reports . 4 (7): 685–91.
doi :
10.1038/sj.embor.embor872 .
PMC
1326318 .
PMID
12835755 .
Loayza D, Parsons H, Donigian J, Hoke K, de Lange T (Mar 2004).
"DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites" . The Journal of Biological Chemistry . 279 (13): 13241–8.
doi :
10.1074/jbc.M312309200 .
PMID
14715659 .
Ye JZ, de Lange T (Jun 2004).
"TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex" . Nature Genetics . 36 (6): 618–23.
doi :
10.1038/ng1360 .
PMID
15133513 .
Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology . 6 (7): 673–80.
doi :
10.1038/ncb1142 .
PMID
15181449 .
S2CID
11543383 .
Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004).
"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex" . Genes & Development . 18 (14): 1649–54.
doi :
10.1101/gad.1215404 .
PMC
478187 .
PMID
15231715 .
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J (Oct 2004).
"TIN2 mediates functions of TRF2 at human telomeres" . The Journal of Biological Chemistry . 279 (42): 43799–804.
doi :
10.1074/jbc.M408650200 .
PMID
15292264 .
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (Nov 2004).
"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres" . The Journal of Biological Chemistry . 279 (45): 47264–71.
doi :
10.1074/jbc.M409047200 .
PMID
15316005 .
Liu D, O'Connor MS, Qin J, Songyang Z (Dec 2004).
"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins" . The Journal of Biological Chemistry . 279 (49): 51338–42.
doi :
10.1074/jbc.M409293200 .
PMID
15383534 .
Oh BK, Kim YJ, Park C, Park YN (Jan 2005).
"Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis" . The American Journal of Pathology . 166 (1): 73–80.
doi :
10.1016/S0002-9440(10)62233-X .
PMC
1602303 .
PMID
15632001 .
Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA (Mar 2005).
"Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2" . Journal of Cell Science . 118 (Pt 6): 1321–30.
doi :
10.1242/jcs.01709 .
PMC
2933191 .
PMID
15741234 .
External links
Basic concepts Types Processes and evolution Structures
See also