From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Centromere protein O is a
protein that in humans is encoded by the CENPO
gene .
[5]
[6]
[7] CENPO is involved in
cell proliferation and
cell cycle progression and has been shown to be down-regulated in trisomic
neurospheres a mouse model of
Down Syndrome , resulting in reduced numbers of neural progenitors and
neuroblasts and a severe reduction in numbers of
neurons produced.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000138092 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020652 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol . 8 (5): 446–57.
doi :
10.1038/ncb1396 .
PMID
16622420 .
S2CID
26974412 .
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol . 8 (5): 458–69.
doi :
10.1038/ncb1397 .
PMID
16622419 .
S2CID
205286556 .
^
"Entrez Gene: CENPO centromere protein O" .
^ Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16).
"Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome" . PLOS ONE . 5 (7): e11561.
Bibcode :
2010PLoSO...511561H .
doi :
10.1371/journal.pone.0011561 .
ISSN
1932-6203 .
PMC
2905390 .
PMID
20661276 .
External links
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Obuse C, Yang H, Nozaki N, et al. (2004).
"Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase" . Genes Cells . 9 (2): 105–20.
doi :
10.1111/j.1365-2443.2004.00705.x .
PMID
15009096 .
S2CID
21813024 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Hillier LW, Graves TA, Fulton RS, et al. (2005).
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31.
Bibcode :
2005Natur.434..724H .
doi :
10.1038/nature03466 .
PMID
15815621 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Izuta H, Ikeno M, Suzuki N, et al. (2006).
"Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells" . Genes Cells . 11 (6): 673–84.
doi :
10.1111/j.1365-2443.2006.00969.x .
PMID
16716197 .
S2CID
45931410 .
Basic concepts Types Processes and evolution Structures
See also