From Wikipedia, the free encyclopedia
Halichondria produces the
eribulin (Halaven ) precursor
halichondrin B
Lacking an
immune system , protective shell, or mobility,
sponges have developed an ability to synthesize a variety of unusual compounds for survival. C-
nucleosides isolated from Caribbean
Cryptotethya crypta , were the basis for the synthesis of
zidovudine (AZT ),
aciclovir (Cyclovir ),
cytarabine (Depocyt ), and cytarabine derivative
gemcitabine (Gemzar ).
Semisynthetic analogs of the sponge isolate jasplakinolide, were submitted to
National Cancer Institute ’s Biological Evaluation Committee in 2011.
Other marine isolates
Trabectedin ,
aplidine ,
didemnin , were isolated from
sea squirts .
Monomethyl auristatin E is a derivative of a dolastatin 10, a compound made by
Dolabella auricularia .
Bryostatins were first isolated from
Bryozoa .
Salinosporamides are derived from
Salinispora tropica .
Ziconotide is derived from the sea snail
Conus magus .
See also
References
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