From Wikipedia, the free encyclopedia
RsaOG (an acronym for
RNA
S. aureus
Orsay G)
[2] is a
non-coding RNA that was discovered in the
pathogenic bacteria Staphylococcus aureus N315 using a large scale
computational screening based on
phylogenetic profiling.
[3] It was first identified, but not named, in 2005.
[4] RsaOG has since been identified in other strains of Staphylococcus aureus under the name of
RsaI,
[5] it has also been discovered in other members of the
Staphylococcus
genus (such as
Staphylococcus carnosus) but in no other bacteria.
[2]
The RsaOG gene is
conserved in all Staphylococcaceae sequenced
genomes, its
secondary structure contains two highly conserved
unpaired sequences which have the ability to form a
pseudoknot.
[2]
Northern blot experiments show that RsaOG is expressed in several S. aureus strains.
[3]
[5] Mapping of RsaOG ends indicates a size of 146
nucleotides in S. aureus.
[5] RsaOG ncRNA is thought to have
trans-acting regulatory functions, possibly on fine tuning
toxin production or aiding with
invasion.
[2]
See also
References
-
^ Darty K, Denise A, Ponty Y (August 2009).
"VARNA: Interactive drawing and editing of the RNA secondary structure". Bioinformatics. 25 (15): 1974–1975.
doi:
10.1093/bioinformatics/btp250.
PMC
2712331.
PMID
19398448.
- ^
a
b
c
d
e Marchais A, Bohn C, Bouloc P, Gautheret D (March 2010).
"RsaOG, a new staphylococcal family of highly transcribed non-coding RNA". RNA Biol. 7 (2): 116–119.
doi:
10.4161/rna.7.2.10925.
PMID
20200491. Retrieved 2010-07-12.
- ^
a
b Marchais A, Naville M, Bohn C, Bouloc P, Gautheret D (June 2009).
"Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles". Genome Res. 19 (6): 1084–1092.
doi:
10.1101/gr.089714.108.
PMC
2694484.
PMID
19237465.
-
^ Pichon C, Felden B (October 2005).
"Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14249–14254.
doi:
10.1073/pnas.0503838102.
PMC
1242290.
PMID
16183745.
- ^
a
b
c Geissmann T, Chevalier C, Cros MJ, et al. (November 2009).
"A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation". Nucleic Acids Res. 37 (21): 7239–7257.
doi:
10.1093/nar/gkp668.
PMC
2790875.
PMID
19786493.
External links