From Wikipedia, the free encyclopedia
Protein-coding gene in humans
RDH11 Identifiers
Aliases
RDH11 , ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, SCALD, SDR7C1, RDJCSS, retinol dehydrogenase 11 (all-trans/9-cis/11-cis), retinol dehydrogenase 11External IDs
OMIM :
607849 ;
MGI :
102581 ;
HomoloGene :
100724 ;
GeneCards :
RDH11 ;
OMA :
RDH11 - orthologs
Wikidata
Retinol dehydrogenase 11 is an
enzyme that in humans is encoded by the RDH11
gene .
[4]
[5]
[6]
[7]
RHD11, a member of the
short-chain dehydrogenase/reductase (SDR) superfamily of
oxidoreductases , is expressed at high levels in
prostate epithelium, and its expression is regulated by
androgens .[supplied by OMIM]
[7]
Clinical significance
Mutations in RDH11 are associated to
retinitis pigmentosa .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000072042 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Haeseleer F, Jang GF, Imanishi Y, et al. (Nov 2002).
"Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina" . J Biol Chem . 277 (47): 45537–46.
doi :
10.1074/jbc.M208882200 .
PMC
1435693 .
PMID
12226107 .
^ Hara T, Harada N, Mitsui H, et al. (Aug 1994).
"Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line" . Blood . 84 (1): 189–99.
doi :
10.1182/blood.V84.1.189.189 .
PMID
8018917 .
^
^
a
b
"Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)" .
^ Xie YA, Lee W, Cai C, et al. (2014).
"New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11" . Human Molecular Genetics . 23 (21): 5774–5780.
doi :
10.1093/hmg/ddu291 .
PMC
4189905 .
PMID
24916380 .
Further reading
Lai CH, Chou CY, Ch'ang LY, et al. (2000).
"Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics" . Genome Res . 10 (5): 703–13.
doi :
10.1101/gr.10.5.703 .
PMC
310876 .
PMID
10810093 .
Lin B, White JT, Ferguson C, et al. (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium". Cancer Res . 61 (4): 1611–8.
PMID
11245473 .
Kedishvili NY, Chumakova OV, Chetyrkin SV, et al. (2002).
"Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)" . J. Biol. Chem . 277 (32): 28909–15.
doi :
10.1074/jbc.M202588200 .
PMID
12036956 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Li K, Wang L, Cheng J, et al. (2003).
"Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus" . World J. Gastroenterol . 9 (2): 300–3.
doi :
10.3748/wjg.v9.i2.300 .
PMC
4611333 .
PMID
12532453 .
Belyaeva OV, Stetsenko AV, Nelson P, et al. (2004). "Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines". Biochemistry . 42 (50): 14838–45.
doi :
10.1021/bi035288u .
PMID
14674758 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26.
doi :
10.1093/dnares/12.2.117 .
PMID
16303743 .
Kasus-Jacobi A, Birch DG, Anderson RE (2006). "Photoreceptor Retinol Dehydrogenases".
Retinal Degenerative Diseases . Advances in Experimental Medicine and Biology. Vol. 572. pp.
505–11 .
doi :
10.1007/0-387-32442-9_70 .
ISBN
978-0-387-28464-4 .
PMID
17249616 .
Roni V, Carpio R, Wissinger B (2007).
"Mapping of transcription start sites of human retina expressed genes" . BMC Genomics . 8 : 42.
doi :
10.1186/1471-2164-8-42 .
PMC
1802077 .
PMID
17286855 .