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Paula Elaine Cohen
Cohen at a 2020 discussion for the R Street Institute
Alma mater University of London
King's College London
Scientific career
Institutions Albert Einstein College of Medicine
Cornell University
Thesis Studies on the endocrine control of implantation (1993)

Paula Elaine Cohen is a British-American geneticist who is a professor and Associate Vice Provost for Life Sciences at Cornell University. Her research considers DNA repair mechanisms and the regulation of crossing over during mammalian meiosis. She was awarded the National Down Syndrome Society Charles J. Epstein Down Syndrome Research Award in 2004 and elected Fellow of the American Association for the Advancement of Science in 2021.

Early life and education

Cohen was born and raised in Nigeria. She attended boarding school in England from the age of 8 and then her family moved back to their native England when she was 11 years old. Cohen was an undergraduate student at King's College London, where she majored in animal physiology. She was a doctoral researcher at the University of London, where she worked toward a PhD in reproductive physiology. During her doctorate she was based at Guy's and St Thomas' NHS Foundation Trust.[ citation needed] Her research considered endocrine control during implantation. [1] After earning her doctorate she moved to the United States, where she worked as a postdoctoral researcher at the Albert Einstein College of Medicine. [2]

Research and career

Cohen joined the faculty at Albert Einstein College of Medicine in 2000. Her early research considered gonadal function in males and females. [2] Specifically, she worked on maternal mismatch repair proteins and how they impact Trisomy-21. [3] Trisomy-21 is the abnormality in chromosomes that is responsible for Down syndrome. [3] She moved to Cornell University in 2004, where she was made associate professor in 2007 and professor in 2013.[ citation needed] She founded the Cornell Center for Reproductive Genomics in 2006, which seeks to promote research in reproductive health and fertility. [4] She was appointed Associate Vice Provost for Life Sciences in 2018. [5]

Cohen is interested in mammalian meiosis, gametogenesis and the role of a variety of DNA repair pathways in mediating meiosis. In particular, Cohen has studied the DNA mismatch repair (MMR) pathway, and described the major crossover pathway in mammalian meiosis. [6] She has also studied the origins of male infertility and spermatogenesis. [7] Specifically, Cohen is interested in the regulation of RNA during the formation of sperm. [7]

Cohen is chair of the 2022 Gordon Research Conference Diverse and Conserved Molecular Mechanisms Preventing Aneuploidy During Gamete Production. [8] The conference looks to explore meiosis, the cell division process that results in gametes for sexual reproduction. [8]

Awards and honours

Selected publications

  • W. Edelmann; P. E. Cohen; M. Kane; et al. (28 June 1996). "Meiotic pachytene arrest in MLH1-deficient mice". Cell. 85 (7): 1125–1134. doi: 10.1016/S0092-8674(00)81312-4. ISSN  0092-8674. PMID  8674118. Wikidata  Q28510650.
  • B Kneitz; P E Cohen; E Avdievich; et al. (1 May 2000). "MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice". Genes & Development. 14 (9): 1085–1097. ISSN  0890-9369. PMC  316572. PMID  10809667. Wikidata  Q24606421.
  • W Edelmann; P E Cohen; B Kneitz; et al. (January 1999). "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis". Nature Genetics. 21 (1): 123–7. doi: 10.1038/5075. ISSN  1061-4036. PMID  9916805. Wikidata  Q28295022.

References

  1. ^ Cohen, Paula Elaine (1993). Studies on the endocrine control of implantation (Thesis). London: University of London. OCLC  223094639.
  2. ^ a b "Paula Cohen, PhD". Cornell University College of Veterinary Medicine. 2017-01-11. Retrieved 2022-02-09.
  3. ^ a b c "Einstein Researcher Receives Charles J. Epstein Down Syndrome Research Award from the National Down Syndrome Society". Albert Einstein College of Medicine. Retrieved 2022-02-09.
  4. ^ "CRG @ Cornell". reprogenomics.cornell.edu. Retrieved 2022-02-09.
  5. ^ "Paula Cohen named provost fellow for life sciences". Cornell University College of Veterinary Medicine. 2018-06-27. Retrieved 2022-02-09.
  6. ^ "Dr. Paula Cohen". reprogenomics.cornell.edu. Retrieved 2022-02-09.
  7. ^ a b "NIH-funded research to address rising male infertility". Cornell Chronicle. Retrieved 2022-02-09.
  8. ^ a b "2022 Meiosis Conference GRC". www.grc.org. Retrieved 2022-02-09.
  9. ^ "Eight receive Provost's Award for Distinguished Scholarship". Cornell Chronicle. Retrieved 2022-02-09.
  10. ^ "Chancellor's Awards for Excellence Recipients Academic Year 2016-2017" (PDF).
  11. ^ "2021 AAAS Fellows | American Association for the Advancement of Science". www.aaas.org. Retrieved 2022-02-09.
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