From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Pannexin 1 is a
protein in humans that is encoded by the PANX1
gene .
[5]
The protein encoded by this gene belongs to the
innexin family. Innexin family members are the structural components of
gap junctions . This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in
Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
[5]
Clinical relevance
Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to survive mechanical stretch in the microcirculation.
[6]
Disruptions of this gene have been associated to melanoma tumor progression.
[7]
Pannexin 1 is also an important component of membrane channels involved in the formation of thin plasma membrane extensions called
apoptopodia and
beaded apoptopodia during
apoptosis .
[8]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000110218 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031934 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: Pannexin 1" . Retrieved 2012-04-11 .
^ Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento O, Tavazoie SF (July 2015).
"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival" . Nature Cell Biology . 17 (7): 943–952.
doi :
10.1038/ncb3194 .
PMC
5310712 .
PMID
26098574 .
^ Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW (Aug 2012).
"Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype" . The Journal of Biological Chemistry . 287 (34): 29184–93.
doi :
10.1074/jbc.M112.377176 .
PMC
3436541 .
PMID
22753409 .
^ Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS (2014).
"Unexpected link between an antibiotic, pannexin channels and apoptosis" . Nature . 507 (7492): 329–34.
Bibcode :
2014Natur.507..329P .
doi :
10.1038/nature13147 .
PMC
4078991 .
PMID
24646995 .
^ Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD, Poon IK (2015).
"A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure" . Nat Commun . 6 : 7439.
Bibcode :
2015NatCo...6.7439A .
doi :
10.1038/ncomms8439 .
PMC
4490561 .
PMID
26074490 .
Further reading
Pelegrin P, Surprenant A (Nov 2006).
"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor" . The EMBO Journal . 25 (21): 5071–82.
doi :
10.1038/sj.emboj.7601378 .
PMC
1630421 .
PMID
17036048 .
Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (Nov 2003).
"Pannexins, a family of gap junction proteins expressed in brain" . Proceedings of the National Academy of Sciences of the United States of America . 100 (23): 13644–9.
Bibcode :
2003PNAS..10013644B .
doi :
10.1073/pnas.2233464100 .
PMC
263867 .
PMID
14597722 .
Reyes JP, Hernández-Carballo CY, Pérez-Flores G, Pérez-Cornejo P, Arreola J (Feb 2009).
"Lack of coupling between membrane stretching and pannexin-1 hemichannels" . Biochemical and Biophysical Research Communications . 380 (1): 50–3.
doi :
10.1016/j.bbrc.2009.01.021 .
PMC
2670310 .
PMID
19150332 .
Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C (Jul 2011).
"Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma" . JAMA . 306 (4): 410–9.
doi :
10.1001/jama.2011.1029 .
PMC
3574553 .
PMID
21791690 .
Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE (Aug 2010).
"Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other" . The Journal of Biological Chemistry . 285 (32): 24420–31.
doi :
10.1074/jbc.M110.115444 .
PMC
2915678 .
PMID
20516070 .
Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG (Nov 2010).
"Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse" . Blood . 116 (18): 3475–84.
doi :
10.1182/blood-2010-04-277707 .
PMC
2981474 .
PMID
20660288 .
Boassa D, Ambrosi C, Qiu F, Dahl G, Gaietta G, Sosinsky G (Oct 2007).
"Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane" . The Journal of Biological Chemistry . 282 (43): 31733–43.
doi :
10.1074/jbc.M702422200 .
PMID
17715132 .
Baranova A, Ivanov D, Petrash N, Pestova A, Skoblov M, Kelmanson I, Shagin D, Nazarenko S, Geraymovych E, Litvin O, Tiunova A, Born TL, Usman N, Staroverov D, Lukyanov S, Panchin Y (Apr 2004). "The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins". Genomics . 83 (4): 706–16.
doi :
10.1016/j.ygeno.2003.09.025 .
PMID
15028292 .
Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW (Mar 2010).
"Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions" . The Journal of Biological Chemistry . 285 (12): 9147–60.
doi :
10.1074/jbc.M109.082008 .
PMC
2838334 .
PMID
20086016 .