From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DNA polymerase delta subunit 3 is an
enzyme that in humans is encoded by the POLD3
gene .
[5]
[6] It is a component of the
DNA polymerase delta complex.
Interactions
POLD3 has been shown to
interact with
PCNA .
[7]
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000077514 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000030726 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999).
"Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts" . Nucleic Acids Res . 27 (10): 2108–14.
doi :
10.1093/nar/27.10.2108 .
PMC
148430 .
PMID
10219083 .
^
"Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit" .
^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001).
"Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta" . J. Biol. Chem . 276 (52): 49258–66.
doi :
10.1074/jbc.M106990200 .
PMID
11595739 .
^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002).
"A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein" . J. Biol. Chem . 277 (43): 40362–7.
doi :
10.1074/jbc.M206194200 .
PMID
12171929 .
Further reading
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995).
"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35.
doi :
10.1093/dnares/1.1.27 .
PMID
7584026 .
Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994).
"DNA polymerase delta is involved in the cellular response to UV damage in human cells" . J. Biol. Chem . 269 (19): 13748–51.
doi :
10.1016/S0021-9258(17)36709-1 .
PMID
7910606 .
Longley MJ, Pierce AJ, Modrich P (1997).
"DNA polymerase delta is required for human mismatch repair in vitro" . J. Biol. Chem . 272 (16): 10917–21.
doi :
10.1074/jbc.272.16.10917 .
PMID
9099749 .
Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry . 39 (24): 7245–54.
doi :
10.1021/bi0000871 .
PMID
10852724 .
Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002).
"Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta" . J. Biol. Chem . 276 (52): 49258–66.
doi :
10.1074/jbc.M106990200 .
PMID
11595739 .
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002).
"A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein" . J. Biol. Chem . 277 (43): 40362–7.
doi :
10.1074/jbc.M206194200 .
PMID
12171929 .
Pohler JR, Otterlei M, Warbrick E (2006).
"An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit" . BMC Mol. Biol . 6 : 17.
doi :
10.1186/1471-2199-6-17 .
PMC
1187890 .
PMID
16000169 .
Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). "Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase". Biochim. Biophys. Acta . 1764 (9): 1447–53.
doi :
10.1016/j.bbapap.2006.06.015 .
PMID
16935576 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007).
"Dynamics of human replication factors in the elongation phase of DNA replication" . Nucleic Acids Res . 35 (20): 6904–16.
doi :
10.1093/nar/gkm822 .
PMC
2175312 .
PMID
17932049 .