From Wikipedia, the free encyclopedia
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase (
EC
2.9.1.2 , MMPSepSecS ,
SepSecS , SLA/LP , O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase , O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase ) is an
enzyme with
systematic name selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase .
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
O-phospho-L-seryl-tRNASec +
selenophosphate ⇌ L-selenocysteinyl-tRNASec +
phosphate
This enzyme is
pyridoxal -
phosphate protein.
References
^ Palioura S, Sherrer RL, Steitz TA, Söll D, Simonovic M (July 2009).
"The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation" . Science . 325 (5938): 321–5.
Bibcode :
2009Sci...325..321P .
doi :
10.1126/science.1173755 .
PMC
2857584 .
PMID
19608919 .
^ Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Söll D, Nureki O (March 2008).
"Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation" . Nucleic Acids Research . 36 (4): 1187–99.
doi :
10.1093/nar/gkm1122 .
PMC
2275076 .
PMID
18158303 .
^ Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Söll D, Schneider A (March 2009).
"The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes" . Proceedings of the National Academy of Sciences of the United States of America . 106 (13): 5088–92.
Bibcode :
2009PNAS..106.5088A .
doi :
10.1073/pnas.0901575106 .
PMC
2664009 .
PMID
19279205 .
^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (December 2006).
"RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea" . Proceedings of the National Academy of Sciences of the United States of America . 103 (50): 18923–7.
Bibcode :
2006PNAS..10318923Y .
doi :
10.1073/pnas.0609703104 .
PMC
1748153 .
PMID
17142313 .
External links
Activity Regulation Classification Kinetics Types