Microsomal glutathione S-transferase 1 is an
enzyme that in humans is encoded by the MGST1gene.[5]
Function
The
MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of
leukotrienes and
prostaglandin E, important mediators of
inflammation. Other family members, demonstrating
glutathione S-transferase and
peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of
glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the
endoplasmic reticulum and outer
mitochondrial membrane where it is thought to protect these membranes from
oxidative stress. Four
transcript variants of this gene encode one protein
isoform.[5]
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doi:
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PMID8812420.
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doi:
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PMID10095775.
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doi:
10.1016/S0167-4781(99)00112-8.
PMID10524215.
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doi:
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PMID12359356.
Ekström L, Lyrenäs L, Jakobsson PJ (2003). "Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3". Biochim. Biophys. Acta. 1627 (2–3): 79–84.
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