Route 380 or Highway 380 may refer to:

Canada

• New Brunswick Route 380
• Newfoundland and Labrador Route 380

Japan

• Japan National Route 380

United States

• Interstate 380
• U.S. Route 380
• Arizona State Route 380 (cancelled proposal)
• Arkansas Highway 380
• Georgia State Route 380
• Louisiana Highway 380
• Maryland Route 380
• New York State Route 380 (former)
• Ohio State Route 380
• Oregon Route 380
• Pennsylvania Route 380
• Puerto Rico Highway 380
• Tennessee State Route 380

This article includes a list of roads, streets, highways, or other routes that are associated with the same title.
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