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Chemical compound
L-163,491
Legal status
Butyl (4'-((2-ethyl-5,7-dimethyl-3H -imidazo[4,5-b ]pyridin-3-yl)methyl)-5-(3-methoxybenzyl)-[1,1'-biphenyl]-2-yl)sulfonylcarbamate
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
Formula C 36 H 40 N 4 O 5 S
Molar mass 640.80 g·mol−1 3D model (
JSmol )
CCCCOC(=O)NS(=O)(=O)C1=C(C=C(C=C1)CC2=CC(=CC=C2)OC)C3=CC=C(C=C3)CN4C(=NC5=C4N=C(C=C5C)C)CC
InChI=1S/C36H40N4O5S/c1-6-8-18-45-36(41)39-46(42,43)32-17-14-28(20-27-10-9-11-30(21-27)44-5)22-31(32)29-15-12-26(13-16-29)23-40-33(7-2)38-34-24(3)19-25(4)37-35(34)40/h9-17,19,21-22H,6-8,18,20,23H2,1-5H3,(H,39,41)
Key:SRCIRAKBWHTYIX-UHFFFAOYSA-N
L-163,491 is an experimental drug which acts as a
partial agonist of
angiotensin II receptor type 1 , and with lower affinity as an agonist of
angiotensin II receptor type 2 , mimicking the action of
angiotensin II .
[1] Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system,
[2] but it has been suggested as a potential therapeutic agent for the treatment of
inflammation of the lungs associated with certain viral diseases such as
COVID-19 .
[3]
[4]
References
^ De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ (September 2000). "L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat". European Journal of Pharmacology . 404 (1–2): 213–9.
doi :
10.1016/s0014-2999(00)00612-9 .
PMID
10980281 .
^ Alterman M (March 2010).
"Development of selective non-peptide angiotensin II type 2 receptor agonists" . Journal of the Renin-Angiotensin-Aldosterone System . 11 (1): 57–66.
doi :
10.1177/1470320309347790 .
PMID
19880657 .
^ Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ, et al. (2020).
"Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases" . ACS Central Science . 6 (3): 315–331.
doi :
10.1021/acscentsci.0c00272 .
PMC
7094090 .
PMID
32226821 .
^ Wu Y (February 2020).
"Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury" . Virologica Sinica . 35 (3): 256–258.
doi :
10.1007/s12250-020-00205-6 .
PMC
7091449 .
PMID
32034638 .
ATR Tooltip Angiotensin receptor Combinations: