![]() | |
Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C26H32N2O5 |
Molar mass | 452.551 g·mol−1 |
3D model ( JSmol) | |
| |
| |
![]() ![]() |
Delapril ( INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug [1] in some European and Asian countries but not in America. [2] It is taken orally, available in 15 mg and 30 mg tablets. [3]
Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow. [4]