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Gene found in fruit flies
Indy , short for I'm not dead yet , is a
gene found in the fruit fly
Drosophila melanogaster , an important
model organism . Mutant versions of this gene have doubled the average
life span of fruit flies in at least one set of experiments, but this result has been subject to controversy. Both Indy proteins are
sodium sulfate symporters .
[1] Its name originates from a well-known comic line in
Monty Python and the Holy Grail .
[2]
Reduced expression of this gene in Drosophila melanogaster flies and
C. elegans worms (
P32739 ) modeled the effects on obesity and diabetes of caloric reduction in primates such as humans. A similar effect was seen with
SLC13A5 (mIndy) knockouts of mice.
[3]
[4]
[5]
[6]
See also
References
^ Rogina B, Reenan RA, Nilsen SP, Helfand SL (15 December 2000). "Extended life-span conferred by cotransporter gene mutations in Drosophila". Science . 290 (5499): 2137–40.
Bibcode :
2000Sci...290.2137R .
doi :
10.1126/science.290.5499.2137 .
PMID
11118146 .
^ Niku M, Taipale M (25 March 2003).
"Clever Drosophila gene names" . Archived from
the original on 3 February 2007. Retrieved 15 February 2007 .
^
"Diet, diabetes, and a gene called mINDY" . Yale School of Medicine. Retrieved 25 May 2019 .
^ Willmes DM, Schumann T, Henke C, Kurzbach A, Luft F, Morawietz H, et al. (2018).
"The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms" . Journal of the American College of Cardiology . 71 (11S): A1813.
doi :
10.1016/S0735-1097(18)32354-4 .
^ Willmes DM, Daniels M, Kurzbach A, Lieske S, Bechmann N, Schumann T, et al. (2021).
"The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms" . JCI Insight . 6 (2): e136083.
doi :
10.1172/jci.insight.136083 .
PMC
7934862 .
PMID
33491666 .
^
"The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation" . Medical Xpress . 2021.
External links