From Wikipedia, the free encyclopedia
Hypothalamic obesity (abbreviated HO or HyOb) is a rare condition that can be congenital or acquired. Congenital causes include
Prader-Willi syndrome and mutations of LEP (
leptin gene),
LEPR,
POMC,
MC4R, and
CART. It can also result from injuries to the
hypothalamus either from trauma, therapeutic radiation, brain surgery, and especially
craniopharyngioma and its treatments. Possible treatments include
bariatric surgery and
melanocortin 4 receptor agonists such as
setmelanotide.
[1]
[2]
[3]
[4]
References
-
^ Dimitri, Paul (6 April 2022).
"Treatment of Acquired Hypothalamic Obesity: Now and the Future". Frontiers in Endocrinology. 13: 846880.
doi:
10.3389/fendo.2022.846880.
ISSN
1664-2392.
PMC
9019363.
PMID
35464063.
-
^ Bereket, A.; Kiess, W.; Lustig, R. H.; Muller, H. L.; Goldstone, A. P.; Weiss, R.; Yavuz, Y.; Hochberg, Z. (September 2012). "Hypothalamic obesity in children". Obesity Reviews. 13 (9): 780–798.
doi:
10.1111/j.1467-789X.2012.01004.x.
PMID
22577758.
S2CID
9550333.
-
^ Abuzzahab, M. Jennifer; Roth, Christian L.; Shoemaker, Ashley H. (2019).
"Hypothalamic Obesity: Prologue and Promise". Hormone Research in Paediatrics. 91 (2): 128–136.
doi:
10.1159/000496564.
PMID
30884480.
S2CID
83460590.
-
^ Kim, Ja Hye; Choi, Jin-Ho (December 2013).
"Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents". Annals of Pediatric Endocrinology & Metabolism. 18 (4): 161–167.
doi:
10.6065/apem.2013.18.4.161.
ISSN
2287-1012.
PMC
4027083.
PMID
24904871.