From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Histone deacetylase 10 is an
enzyme that in humans is encoded by the HDAC10
gene .
[5]
[6]
[7]
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]
[7]
Interactions
HDAC10 has been shown to
interact with
Histone deacetylase 2
[8] and
Nuclear receptor co-repressor 2 .
[8]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000100429 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000062906 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002).
"Isolation and characterization of mammalian HDAC10, a novel histone deacetylase" . J Biol Chem . 277 (1): 187–93.
doi :
10.1074/jbc.M108931200 .
PMID
11677242 .
^ Guardiola AR, Yao TP (Jan 2002).
"Molecular cloning and characterization of a novel histone deacetylase HDAC10" . J Biol Chem . 277 (5): 3350–6.
doi :
10.1074/jbc.M109861200 .
PMID
11726666 .
^
a
b
"Entrez Gene: HDAC10 histone deacetylase 10" .
^
a
b Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002).
"Isolation and characterization of a novel class II histone deacetylase, HDAC10" . J. Biol. Chem . 277 (8). United States: 6656–66.
doi :
10.1074/jbc.M108055200 .
ISSN
0021-9258 .
PMID
11739383 .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Dunham I, Shimizu N, Roe BA, et al. (1999).
"The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95.
Bibcode :
1999Natur.402..489D .
doi :
10.1038/990031 .
PMID
10591208 .
Fischer DD, Cai R, Bhatia U, et al. (2002).
"Isolation and characterization of a novel class II histone deacetylase, HDAC10" . J. Biol. Chem . 277 (8): 6656–66.
doi :
10.1074/jbc.M108055200 .
PMID
11739383 .
Tong JJ, Liu J, Bertos NR, Yang XJ (2002).
"Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain" . Nucleic Acids Res . 30 (5): 1114–23.
doi :
10.1093/nar/30.5.1114 .
PMC
101247 .
PMID
11861901 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Rodriguez M, Yu X, Chen J, Songyang Z (2004).
"Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains" . J. Biol. Chem . 278 (52): 52914–8.
doi :
10.1074/jbc.C300407200 .
PMID
14578343 .
Hillman RT, Green RE, Brenner SE (2005).
"An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8.
doi :
10.1186/gb-2004-5-2-r8 .
PMC
395752 .
PMID
14759258 .
Osada H, Tatematsu Y, Saito H, et al. (2004).
"Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients" . Int. J. Cancer . 112 (1): 26–32.
doi :
10.1002/ijc.20395 .
PMID
15305372 .
S2CID
23452893 .
Collins JE, Wright CL, Edwards CA, et al. (2005).
"A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84.
doi :
10.1186/gb-2004-5-10-r84 .
PMC
545604 .
PMID
15461802 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Activity Regulation Classification Kinetics Types