From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
Hemoglobin subunit theta-1 is a
protein that in humans is encoded by the HBQ1
gene .
[5]
[6]
Theta-globin mRNA is found in human
fetal erythroid tissue but not in adult
erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' -
zeta - pseudozeta -
mu - pseudoalpha-1 -
alpha-2 -
alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000086506 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000073063 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989).
"A review of the molecular genetics of the human alpha-globin gene cluster" . Blood . 73 (5): 1081–104.
doi :
10.1182/blood.V73.5.1081.1081 .
PMID
2649166 .
^
a
b
"Entrez Gene: HBQ1 hemoglobin, theta 1" .
Further reading
Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol . 30 (3): 165–96.
doi :
10.3109/10409239509085142 .
PMID
7555018 .
Kim JH, Yu CY, Bailey A, et al. (1989).
"Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters" . Nucleic Acids Res . 17 (14): 5687–700.
doi :
10.1093/nar/17.14.5687 .
PMC
318189 .
PMID
2569721 .
Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989).
"Globin gene expression in erythroid human fetal liver cells" . J. Clin. Invest . 83 (3): 1032–8.
doi :
10.1172/JCI113944 .
PMC
303780 .
PMID
2921315 .
Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene". Biochem. Genet . 26 (3–4): 207–11.
doi :
10.1007/BF00561460 .
PMID
3408475 .
S2CID
19352648 .
Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature . 331 (6151): 94–6.
Bibcode :
1988Natur.331...94H .
doi :
10.1038/331094a0 .
PMID
3422341 .
S2CID
4357357 .
Daniels RJ, Peden JF, Lloyd C, et al. (2001).
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16" . Hum. Mol. Genet . 10 (4): 339–52.
doi :
10.1093/hmg/10.4.339 .
PMID
11157797 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science . 312 (5777): 1215–7.
Bibcode :
2006Sci...312.1215D .
doi :
10.1126/science.1126431 .
PMID
16728641 .
S2CID
16044469 .