Cytoglobin is a
globin molecule ubiquitously expressed in all tissues and most notably utilized in
marine mammals. It was discovered in 2001[6] and named cytoglobin in 2002.[7] It is thought to protect against
hypoxia. The predicted function of cytoglobin is the transfer of oxygen from arterial blood to the brain.[8]
Function
Cytoglobin is a ubiquitously expressed
hexacoordinatehemoglobin that may facilitate diffusion of oxygen through tissues, scavenge
nitric oxide or reactive oxygen species, or serve a protective function during
oxidative stress.[5][9]
Applications
CYGB expression can be used as a specific marker with which
hepatic stellate cells can be distinguished from portal
myofibroblasts in the damaged human liver.[10]
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