From Wikipedia, the free encyclopedia
Cell type
Gonadotropic cells (called also gonadotropes, gonadotrophs, delta cells or delta basophils)
[1] are
endocrine
cells in the
anterior pituitary that produce the
gonadotropins , such as the
follicle-stimulating hormone (FSH) and
luteinizing hormone (LH). Release of FSH and LH by gonadotropes is regulated by
gonadotropin-releasing hormone (GnRH) from the
hypothalamus .
[2]
Gonadotropes appear
basophilic in histological preparations.
Gonadotropes have insulin receptors, which can be overstimulated by too high insulin levels. This may lead to infertility as hormone release levels are disrupted.
[3]
[4]
Gonadotropes are feedback inhibited by specific hormones, including estradiol.
[5]
See also
References
^ DOUGLAS, ANDERSON (2012). Dorland's Illustrated Medical Dictionary, 32 edition . USA: Elsevier. p. 797.
ISBN
978-1-4160-6257-8 .
^ Ganong, William F.: "Review of Medical Physiology", page 248. Lange, 2005.
^ Brothers, K. J.; Wu, S.; Divall, S. A.; Messmer, M. R.; Kahn, C. R.; Miller, R. S.; Radovick, S.; Wondisford, F. E.; Wolfe, A. (2010).
"Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR)" . Cell Metabolism . 12 (3): 295–305.
doi :
10.1016/j.cmet.2010.06.010 .
PMC
2935812 .
PMID
20816095 .
^ Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK (2010).
"Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility" . Cell Metabolism . 11 (4): 286–97.
doi :
10.1016/j.cmet.2010.03.002 .
PMC
2854520 .
PMID
20374961 .
^ Iqbal, Javed; Latchoumanin, Olivier; Sari, Ika P.; Lang, Richard J.; Coleman, Harold A.; Parkington, Helena C.; Clarke, Iain J. (2009-09-01).
"Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release" . Endocrinology . 150 (9): 4213–4220.
doi :
10.1210/en.2009-0092 .
ISSN
1945-7170 .
PMID
19477939 .