British statistical geneticist (born 1973)
Gilean Alistair Tristram McVean
FRS
FMedSci
[5] (born February 1973)
[6] is a professor of statistical
genetics at the
University of Oxford ,
[7] fellow of
Linacre College, Oxford and co-founder and director of
Genomics plc .
[6]
[8] He also co-chaired the
1000 Genomes Project analysis group.
[9]
[10]
Education
Gilean McVean speaking at the 2010 GEM meeting at the
Wellcome Trust Sanger Institute, Hinxton
From 1991-94, he completed a
Bachelor of Arts degree in Biological Sciences at the University of Oxford.
[11] He completed his
PhD in the Department of Genetics at the
University of Cambridge supervised by
Laurence Hurst
[12]
[13] in 1998.
[3]
[14]
Career and research
McVean completed
postdoctoral research at the
University of Edinburgh from 1997 to 2000, supervised by
Brian and
Deborah Charlesworth .
[15]
[14]
From 2000-04, he was a
Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.
[16] In October 2006, he was appointed professor of statistical genetics at the University of Oxford.
[17]
McVean's research
[18] focuses on
population genetics , statistics
[19] and
evolutionary biology including the
International HapMap Project ,
[20]
[21] recombination rates in the
human genome
[22] and the
1000 Genomes Project .
[23]
[24]
McVean developed a statistical method to look at recombination rate which helped to identify
PRDM9 as a hotspot positioning gene.
[25] In 2014, with
Peter Donnelly , McVean co-founded Genomics plc, a genomics analysis company, as a
corporate spin-off of the University of Oxford.
[6] In 2017, he was a founding director of the
Big Data Institute at the University of Oxford.
[26]
Honours and awards
In 2006 McVean was awarded a
Philip Leverhulme Prize .
[27]
[28]
In 2010, McVean was awarded the
Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".
[29]
In 2012, he was awarded the
Weldon Memorial Prize .
[30]
In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories .
[31]
In May 2014, McVean was elected as a member of the
European Molecular Biology Organisation .
[32]
McVean was elected
Fellow of the Royal Society (FRS) in 2016
[5] and a
Fellow of the Academy of Medical Sciences (FMedSci).
[33]
[34]
References
^
"Francis Crick Medal and Lecture 2010 - Our genomes, our history" . Royal Society . Retrieved 27 January 2022 .
^ Hurst, L.; McVean, G. (1996).
"A difficult phase for introns-early. Molecular evolution" . Current Biology . 6 (5): 533–36.
doi :
10.1016/S0960-9822(02)00535-3 .
PMID
8805261 .
^
a
b McVean, Gilean Alistair Tristram (1998).
Adaptation and conflict: the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge.
OCLC
894602716 .
^
"Students and post-docs past and present in the Hurst laboratory" . University of Bath. Archived from
the original on 15 May 2015.
^
a
b Anon (2016).
"Gilean McVean" . royalsociety.org . London:
Royal Society . Archived from
the original on 29 April 2016.
^
a
b
c Anon (2016).
"Gilean MCVEAN Profile" . companieshouse.gov.uk . London:
Companies House . Archived from
the original on 12 August 2016.
^
McVean Group at the University of Oxford
^
"Prof. Gil McVean - GENOMICS plc" . Retrieved 30 December 2017 .
^
"Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics" . www.well.ox.ac.uk . Archived from
the original on 10 September 2018. Retrieved 30 December 2017 .
^
Gil McVean publications from
Europe PubMed Central
^ Gil McVean's
ORCID
0000-0002-5012-4162
^ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature . 386 (6623): 388–92.
Bibcode :
1997Natur.386..388M .
doi :
10.1038/386388a0 .
PMID
9121553 .
S2CID
4343123 .
^ Hurst, L.D.; McVean, G.T. (1996).
"...And scandalous symbionts" . Nature . 381 (6584): 650–51.
Bibcode :
1996Natur.381..650H .
doi :
10.1038/381650a0 .
PMID
8649507 .
^
a
b
"Gilean McVean profile" . Oxford University . Archived from
the original on 24 October 2017. Retrieved 30 December 2017 .
^ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution . 16 (5): 235–42.
doi :
10.1016/S0169-5347(01)02126-7 .
PMID
11301152 .
^
"Oxford University Gazette - Reappointments" . ox.ac.uk . 14 May 2009. Archived from
the original on 30 May 2009. Retrieved 30 December 2017 .
^
"Oxford University Gazette" . ox.ac.uk . Archived from
the original on 2 October 2013. Retrieved 12 July 2016 .
^
Gilean McVean profile ,
Google Scholar ; accessed 30 December 2017.
^ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.;
McVean, G. ; Turnbaugh, P. J.;
Lander, E. S. ; Mitzenmacher, M.;
Sabeti, P. C. (2011).
"Detecting Novel Associations in Large Data Sets" . Science . 334 (6062): 1518–1524.
Bibcode :
2011Sci...334.1518R .
doi :
10.1126/science.1205438 .
PMC
3325791 .
PMID
22174245 .
^ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; et al. (2007).
"A second generation human haplotype map of over 3.1 million SNPs" . Nature . 449 (7164): 851–61.
Bibcode :
2007Natur.449..851F .
doi :
10.1038/nature06258 .
PMC
2689609 .
PMID
17943122 .
^
Sabeti, Pardis C. ; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; et al. (2007).
"Genome-wide detection and characterization of positive selection in human populations" . Nature . 449 (7164): 913–918.
Bibcode :
2007Natur.449..913S .
doi :
10.1038/nature06250 .
PMC
2687721 .
PMID
17943131 .
^ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science . 304 (5670): 581–584.
Bibcode :
2004Sci...304..581M .
doi :
10.1126/science.1092500 .
PMID
15105499 .
S2CID
20616898 .
^ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011).
"The Variant Call Format and VCFtools" . Bioinformatics . 27 (15): 2156–58.
doi :
10.1093/bioinformatics/btr330 .
PMC
3137218 .
PMID
21653522 . {{
cite journal }}
: CS1 maint: numeric names: authors list (
link )
^ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011).
"Classic Selective Sweeps Were Rare in Recent Human Evolution" . Science . 331 (6019): 920–24.
Bibcode :
2011Sci...331..920H .
doi :
10.1126/science.1198878 .
PMC
3669691 .
PMID
21330547 . {{
cite journal }}
: CS1 maint: numeric names: authors list (
link )
^
"Gilean McVean" . royalsociety.org . Retrieved 30 December 2017 .
^
"Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute" . www.bdi.ox.ac.uk . Retrieved 29 April 2021 .
^
"AWARDS MADE IN 2006" (PDF) . leverhulme.ac.uk . The Leverhulme Trust. 2006. Archived from
the original (PDF) on 10 August 2016. Retrieved 30 December 2017 .
^
"Philip Leverhulme Prizes 2006" (PDF) . leverhulme.ac.uk . The Leverhulme Trust. 2006. Retrieved 30 December 2017 .
^ The Royal Society (10 December 2013),
Our genomes, our history ,
archived from the original on 15 December 2021, retrieved 30 December 2017
^
"Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics" . well.ox.ac.uk . Retrieved 30 December 2017 .
^ TEDx Talks (29 March 2013),
A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013 ,
archived from the original on 15 December 2021, retrieved 30 December 2017
^
"EMBO enlarges its membership for 50th anniversary" . embo.org . Retrieved 30 December 2017 .
^
"New Fellows: Academy of Medical Sciences" . acmedsci.ac.uk . Retrieved 30 December 2017 .
^
"Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc" . Retrieved 30 December 2017 .
International National Academics