American biologist
"Gerry Rubin" redirects here. For the American social activist, see
Jerry Rubin .
Gerald Mayer Rubin (born 1950) is an American biologist, notable for pioneering the use of
transposable
P elements in
genetics , and for leading the
public project to
sequence the
Drosophila melanogaster
genome . Related to his genomics work, Rubin's lab is notable for development of genetic and
genomics tools and studies of signal transduction and
gene regulation . Rubin also served as a vice president of the
Howard Hughes Medical Institute (2003-2020) and founding executive director of its
Janelia Research Campus .
[2]
[3]
[4]
[5]
Education and early life
Rubin was born in
Boston, Massachusetts , in 1950, attending the
Boston Latin School . Rubin completed his undergraduate degree in biology at
MIT , working at
Cold Spring Harbor Laboratory during the summer.
[6]
[7] He completed his Ph.D. at the
University of Cambridge ,
[8] working at the
Laboratory of Molecular Biology in 1974,
[9] for studies on
5.8S ribosomal RNA supervised by
Sydney Brenner .
[8]
Career and research
Following his PhD, Rubin did
postdoctoral research at
Stanford University with
David Hogness .
[10]
Rubin's first faculty position was at
Harvard Medical School , followed by the
Carnegie Institution of Washington ; in 1983 he accepted an appointment as the John D. MacArthur Professor of Genetics at the
University of California, Berkeley . He was appointed a
Howard Hughes Medical Investigator in 1987. He is currently the MacArthur Professor of Genetics emeritus, Genomics and Development, in Berkeley's Department of Molecular and Cell Biology, and a Senior Group Leader at the Janelia Research Campus.
Rubin has taken a leading role in a number of high-profile scientific research projects.
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21] [
excessive citations ] As the director of the Berkeley Drosophila Genome Project, he led the public effort to sequence
Drosophila melanogaster .
[17] As Vice President of the
Howard Hughes Medical Institute , Rubin led the development of HHMI's
Janelia Research Campus , an independent biomedical research institute in
Virginia .
[6]
His lab is particularly known for its development of
genomics tools, studies of
gene regulation and other genome-wide research, neuroanatomy, and neurogenetics.
He was one of the three scientific founders of
Exelixis in 1994; the company's original business plan was to exploit genomic research in Drosophila and other model organism to discover
biological targets that could be used in drug discovery.
[22]
Awards and honours
Rubin has won numerous awards including:
1971 -
Phi Beta Kappa
1971 - Phi Lambda Epsilon
1971-1973 - United States Churchill Foundation Fellow
1971-1974 -
National Science Foundation (NSF), predoctoral Fellow
1974-1976 -
Helen Hay Whitney Fellow
1983 - AAAS-
Newcomb Cleveland Prize (with Allan C. Spradling for their papers describing germ-line transformation of Drosophila)
[23]
1983 - Co-winner,
Passano Foundation Young Scientist Award
1985 -
American Chemical Society
Eli Lilly Award in Biological Chemistry
1985 - Co-winner, National Academy of Sciences U.S. Steel Foundation Award in Molecular Biology
1986 - Genetics Society of America Medal
1987 -
Member of the National Academy of Sciences USA
[24]
[25]
1992 -
Fellow of the American Association for the Advancement of Science
[26]
1992 - Fellow,
American Academy of Arts and Sciences
[27]
1992 - Fellow,
American Academy of Microbiology
1993 -
Howard Taylor Ricketts Award from The
University of Chicago
2000 - AAAS-
Newcomb Cleveland Prize ,
AAAS (with
Craig Venter , Mark Adams, and
Susan Celniker ) for his March 24, 2000, review paper on sequencing the Drosophila genome
[28]
2002 - Member,
Institute of Medicine
2003 - George W. Beadle Medal (with
Allan C. Spradling )
[1]
2006 - R&D Magazine Scientist of the Year 2006
[29]
2007 - Foreign Member,
Royal Society (UK)
2017 - Member,
European Molecular Biology Organization
2024 -
Gruber Prize in Neuroscience (with
Cornelia Bargmann )
[30]
References
^
a
b Orr-Weaver, T. (2003).
"The 2003 George W. Beadle Medal; Gerald M. Rubin and Allan C. Spradling" . Genetics . 164 (4): 1248–1249.
doi :
10.1093/genetics/164.4.1248 .
PMC
1462668 .
PMID
15106662 .
^
Gerald M. Rubin's publications indexed by the
Scopus bibliographic database. (subscription required)
^ Rubin, G. M. (2006).
"Janelia Farm: An Experiment in Scientific Culture" . Cell . 125 (2): 209–212.
doi :
10.1016/j.cell.2006.04.005 .
PMID
16630805 .
^
"Faculty Research Page" . Department of Molecular & Cell Biology .
^
http://www.sciencewatch.com/sept-oct99/sw_sept-oct99_page3.htm HMI's Gerald M. Rubin: The Benefits of Genomics, ScienceWatch, v.10, n.5 (Sept./Oct. 1999)
^
a
b UPI,
"Gerald Rubin: Science Far Too Conservative ", April 20, 2006 (discussing Janelia Farm).
^
"Gerald M. Rubin" . www.nasonline.org . Retrieved 6 June 2022 .
^
a
b Rubin, Gerald Mayer (1974).
Studies on 5.8 S Ribosomal RNA (PhD thesis). University of Cambridge.
OCLC
500553465 .
EThOS
uk.bl.ethos.471132 .
^ Rubin, G. (1974).
"Three forms of the 5.8-S ribosomal RNA species in Saccharomyces cerevisiae" . European Journal of Biochemistry . 41 (1): 197–202.
doi :
10.1111/j.1432-1033.1974.tb03260.x .
PMID
4593336 .
^ Rubin, G.; Hogness, D. (1975). "Effect of heat shock on the synthesis of low molecular weight RNAs in drosophila: Accumulation of a novel form of 5S RNA". Cell . 6 (2): 207–213.
doi :
10.1016/0092-8674(75)90011-2 .
PMID
810246 .
S2CID
42281700 .
^ Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .
Proceedings of the National Academy of Sciences . 99 (26): 16899–16903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
^ Xu, T; Rubin, G. M. (1993). "Analysis of genetic mosaics in developing and adult Drosophila tissues". Development . 117 (4): 1223–37.
doi :
10.1242/dev.117.4.1223 .
PMID
8404527 .
^ Harris, M. A.; Clark, J; Ireland, A; Lomax, J; Ashburner, M; Foulger, R; Eilbeck, K; Lewis, S; Marshall, B; Mungall, C; Richter, J; Rubin, G. M.; Blake, J. A.; Bult, C; Dolan, M; Drabkin, H; Eppig, J. T.; Hill, D. P.; Ni, L; Ringwald, M; Balakrishnan, R; Cherry, J. M.; Christie, K. R.; Costanzo, M. C.; Dwight, S. S.; Engel, S; Fisk, D. G.; Hirschman, J. E.; Hong, E. L.; et al. (2004).
"The Gene Ontology (GO) database and informatics resource" . Nucleic Acids Research . 32 (Database issue): D258–61.
doi :
10.1093/nar/gkh036 .
PMC
308770 .
PMID
14681407 .
^ Spradling, A.; Rubin, G. (1982). "Transposition of cloned P elements into Drosophila germ line chromosomes". Science . 218 (4570): 341–347.
Bibcode :
1982Sci...218..341S .
doi :
10.1126/science.6289435 .
PMID
6289435 .
^ Rubin, G.; Spradling, A. (1982). "Genetic transformation of Drosophila with transposable element vectors". Science . 218 (4570): 348–353.
Bibcode :
1982Sci...218..348R .
doi :
10.1126/science.6289436 .
PMID
6289436 .
^ Miklos, G.; Rubin, G. (1996).
"The role of the genome project in determining gene function: Insights from model organisms" . Cell . 86 (4): 521–529.
doi :
10.1016/S0092-8674(00)80126-9 .
PMID
8752207 .
S2CID
10526337 .
^
a
b Adams, M.; Celniker, S.; Holt, R.; Evans, C.; Gocayne, J.; Amanatides, P.; Scherer, S.; Li, P.; Hoskins, R.; Galle, R. F.; George, R. A.; Lewis, S. E.; Richards, S.; Ashburner, M.; Henderson, S. N.; Sutton, G. G.; Wortman, J. R.; Yandell, M. D.; Zhang, Q.; Chen, L. X.; Brandon, R. C.; Rogers, Y. H.; Blazej, R. G.; Champe, M.; Pfeiffer, B. D.; Wan, K. H.; Doyle, C.; Baxter, E. G.; Helt, G.; et al. (2000). "The genome sequence of Drosophila melanogaster". Science . 287 (5461): 2185–2195.
Bibcode :
2000Sci...287.2185. .
CiteSeerX
10.1.1.549.8639 .
doi :
10.1126/science.287.5461.2185 .
PMID
10731132 .
^
Rubin, G. ; Yandell, M.; Wortman, J.; Gabor Miklos, G.; Nelson, C.; Hariharan, I.; Fortini, M.; Li, P.; Apweiler, R.; Fleischmann, W.; Cherry, J. M.; Henikoff, S.; Skupski, M. P.; Misra, S.;
Ashburner, M. ;
Birney, E. ; Boguski, M. S.; Brody, T.; Brokstein, P.; Celniker, S. E.; Chervitz, S. A.; Coates, D.; Cravchik, A.; Gabrielian, A.; Galle, R. F.; Gelbart, W. M.; George, R. A.; Goldstein, L. S.; Gong, F.; Guan, P. (2000).
"Comparative genomics of the eukaryotes" . Science . 287 (5461): 2204–2215.
Bibcode :
2000Sci...287.2204. .
doi :
10.1126/science.287.5461.2204 .
PMC
2754258 .
PMID
10731134 .
^
Botstein, D. ; Cherry, J. M.;
Ashburner, M. ; Ball, C. A.; Blake, J. A.; Butler, H.; Davis, A. P.; Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis, A.;
Lewis, S. ; Matese, J. C.; Richardson, J. E.; Ringwald, M.;
Rubin, G. M. ; Sherlock, G. (2000).
"Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium" .
Nature Genetics . 25 (1): 25–29.
doi :
10.1038/75556 .
PMC
3037419 .
PMID
10802651 .
^ Rubin, G. M. (2001).
"The draft sequences: Comparing species" . Nature . 409 (6822): 820–821.
Bibcode :
2001Natur.409..820R .
doi :
10.1038/35057277 .
PMID
11236995 .
^ Spellman, P. T.; Rubin, G. M. (2002).
"Evidence for large domains of similarly expressed genes in the Drosophila genome" . Journal of Biology . 1 (1): 5.
doi :
10.1186/1475-4924-1-5 .
PMC
117248 .
PMID
12144710 .
^ McCarthy, Alice A. (April 2005).
"Exelixis: Integrated Drug-Discovery and Development Platform for Human Therapeutics" (PDF) . Chemistry & Biology . 12 (4): 407–408.
doi :
10.1016/j.chembiol.2005.04.004 .
PMID
15850973 .
^
"1983 AAAS Newcomb Cleveland Prize" . Archived from
the original on 2011-06-07. Retrieved 2016-02-08 .
^ Nair, Prashant (2016).
"QnAs with Gerald M. Rubin" . Proceedings of the National Academy of Sciences . 113 (48): 13543–13545.
Bibcode :
2016PNAS..11313543N .
doi :
10.1073/pnas.1617474113 .
ISSN
0027-8424 .
PMC
5137761 .
PMID
27856746 .
^
"Gerald Rubin" . www.nasonline.org .
^
"Inside AAAS" . 1992.
^
"Gerald Mayer Rubin" .
^ Robert Sanders,
"UC Berkeley's Gerald Rubin shares AAAS prize with Celera's Craig Venter for sequencing genome of the fruit fly" , UC Berkeley Campus News, Feb. 20, 2001.
^
"Architect of the future: refocusing on basic research: R&D Magazine's 41st Scientist of the Year balances genomic research while spearheading one of the newest centers of basic research in the life sciences. (Cover story) - R & D -" . 20 February 2016. Archived from
the original on 2016-02-20.
^
Gruber Prize in Neuroscience 2024
International National Academics