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FV-100
Names
IUPAC name
3-(2-Deoxy-β-D -erythro -pentofuranosyl)-6-(4-pentylphenyl)furo[2,3-d ]pyrimidin-2(3H )-one
Systematic IUPAC name
3-[(2R ,4S ,5R )-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(4-pentylphenyl)furo[2,3-d ]pyrimidin-2(3H )-one
Other names
Cf1743
Identifiers
UNII
CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)[C@H]4C[C@@H]([C@H](O4)CO)O
Properties
C 22 H 26 N 2 O 5
Molar mass
398.459 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
FV-100 , also known as Cf1743 , is an orally available
nucleoside analogue drug
[1] with
antiviral activity.
[2] It may be effective against
shingles .
[3]
It was discovered in 1999 in the laboratories of Prof Chris McGuigan, Welsh School of Pharmacy and Prof. Jan Balzarini, Rega Institute, Leuven, Belgium.
[4]
Clinical trials
FV-100 was tested against
valaciclovir in a
phase II trial in patients with
herpes zoster . The trial was sponsored by Bristol-Myers Squibb.
[5] The drug is currently being developed by
ContraVir Pharmaceuticals, Inc. ,
Edison, New Jersey .
[6] It has reached Phase III clinical trials.
[7]
References
^
Inhibitex Completes Phase I Clinical Trials For FV-100 And Selects Lead HCV Compounds For Advanced Preclinical Studies , 2009
^ McGuigan, Christopher; Balzarini, Jan (2009).
"FV100 as a new approach for the possible treatment of varicella-zoster virus infection" .
Journal of Antimicrobial Chemotherapy . 64 (4): 671–673.
doi :
10.1093/jac/dkp294 .
PMID
19679595 .
^ Tyring SK, Lee P, Hill GT Jr, Silverfield JC, Moore AY, Matkovits T, Sullivan-Bolyai J. FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial. J Med Virol . 2017 Jul;89(7):1255-1264.
doi :
10.1002/jmv.24750
PMID
27943311
^ Cardiff School of Pharmacy; Pharmaceutical Sciences,
Step forward for shingles drug - FV100. Shows structure of FV100.
^
A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster , 23 September 2015
^
ContraVir Pharmaceuticals: FDA Meeting About Antiviral Drug Trial. , January 2015
^ De Clercq E, Li G. Approved Antiviral Drugs over the Past 50 Years. Clin Microbiol Rev . 2016 Jul;29(3):695-747.
doi :
10.1128/CMR.00102-15
PMID
27281742