FGF-2 internal ribosome entry site (IRES) | |
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Identifiers | |
Symbol | IRES_FGF2 |
Alt. Symbols | IRES_FGF; FGF_IRES |
Rfam | RF00224 |
Other data | |
RNA type | Cis-reg; IRES |
Domain(s) | Eukaryota |
GO | GO:0043022 |
SO | SO:0000243 |
PDB structures | PDBe |
The FGF-2 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. It is thought that translational IRES dependent activation of FGF-2 plays a vital role in embryogenesis and in the adult brain [1]. When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and survival as well as being involved in wound-healing [1,2].