From Wikipedia, the free encyclopedia
Exotoxin produced by Pseudomonas aeruginosa
For the Streptococcal superantigen SpeA, also referred to as
exotoxin A, see
Erythrogenic toxin.
The Pseudomonas exotoxin (or exotoxin A) is an
exotoxin produced by
Pseudomonas aeruginosa.
[1]
Vibrio cholerae produces a similar protein called the Cholix toxin (
Q5EK40).
[2]
It inhibits
elongation factor-2. It does so by
ADP-ribosylation of EF2 using
NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of
diphtheria toxin.
[3]
It has been investigated as a treatment for
hepatitis B
[4] and cancer.
[5]
References
-
^ Yates SP, Taylor PL, Jørgensen R, Ferraris D, Zhang J, Andersen GR, Merrill AR (February 2005).
"Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa". The Biochemical Journal. 385 (Pt 3): 667–75.
doi:
10.1042/BJ20041480.
PMC
1134741.
PMID
15458385.
-
^ Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR (April 2008).
"Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae". The Journal of Biological Chemistry. 283 (16): 10671–8.
doi:
10.1074/jbc.M710008200.
PMID
18276581.
-
^ Yates SP, Merrill AR (May 2004).
"Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A". The Biochemical Journal. 379 (Pt 3): 563–72.
doi:
10.1042/BJ20031731.
PMC
1224111.
PMID
14733615.
-
^ Hafkemeyer P, Brinkmann U, Brinkmann E, Pastan I, Blum HE, Baumert TF (May 2008).
"Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells". World Journal of Gastroenterology. 14 (18): 2810–7.
doi:
10.3748/wjg.14.2810.
PMC
2710720.
PMID
18473403.
-
^ Stuckey DW, Hingtgen SD, Karakas N, Rich BE, Shah K (February 2015).
"Engineering toxin-resistant therapeutic stem cells to treat brain tumors". Stem Cells. 33 (2): 589–600.
doi:
10.1002/stem.1874.
PMC
4305025.
PMID
25346520.
External links