From Wikipedia, the free encyclopedia
Biophysicist, professor
Eva Nogales
Nogales in 2023
Born May 16, 1965 (1965-05-16 ) (age 58) Alma mater
B.S. , physics,
Autonomous University of Madrid in 1988, PhD,
University of Keele , 1992 Occupation(s)
Biophysicist , professor Known for The first to determine the atomic structure of
tubulin by
electron crystallography Spouse Howard Padmore Children 2 Awards
Early Career Award ,
American Society for Cell Biology (2005) Chabot Science Award for Excellence (2006)
Shaw Prize (2023) Scientific career Institutions
University of California, Berkeley ,
Howard Hughes Medical Institute ,
Synchrotron Radiation Source
Eva Nogales (born in
Colmenar Viejo ,
Madrid , Spain) is a Spanish-American
biophysicist at the
Lawrence Berkeley National Laboratory and a professor at the
University of California, Berkeley , where she served as head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015–2020). She is a
Howard Hughes Medical Institute investigator.
Nogales is a pioneer in using
electron microscopy for the structural and functional characterization of macromolecular complexes. She used
electron crystallography to obtain the first structure of
tubulin and identify the binding site of the important anti-cancer drug
taxol . She is a leader in combining
cryo-EM , computational image analysis and
biochemical assays to gain insights into function and regulation of biological complexes and
molecular machines .
[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.
[2]
Early life and education
Eva Nogales obtained her BS degree in physics from the
Autonomous University of Madrid in 1988.
[3] She later earned her PhD from the
University of Keele in 1992 while working at the
Synchrotron Radiation Source under the supervision of
Joan Bordas .
[3]
Career
During her post-doctoral work in the laboratory of Ken Downing at the
Lawrence Berkeley National Laboratory , Eva Nogales was the first to determine the atomic structure of
tubulin and the location of the taxol-binding site by
electron crystallography .
[4]
[5]
[6] She became an assistant professor in the Department of Molecular and Cell Biology at the
University of California, Berkeley in 1998. In 2000 she became an investigator in the
Howard Hughes Medical Institute . As
cryo-EM techniques became more powerful,
[7] she became a leader in applying cryo-EM to the study of microtubule structure and function
[8] and other large
macromolecular assemblies such as
eukaryotic transcription and translation initiation complexes,
[9]
[10] the polycomb complex PRC2, and
telomerase .
[11]
Selected publications
Awards
Personal life
Nogales is married to Howard Padmore and they have two children.
[20]
References
^
"How to See Living Machines" . Medical Design Technology . 2016-12-07. Retrieved 2018-02-03 .
^
"Eva Nogales" . HHMI.org . Retrieved 2019-03-23 .
^
a
b
"Nogales Lab – CryoEM – Publications" . cryoem.berkeley.edu . Archived from
the original on 2021-12-25. Retrieved 2022-03-16 .
^ Nogales, E.; Wolf, S. G.; Khan, I. A.; Ludueña, R. F.; Downing, K. H. (1995-06-01). "Structure of tubulin at 6.5 A and location of the taxol-binding site". Nature . 375 (6530): 424–427.
Bibcode :
1995Natur.375..424N .
doi :
10.1038/375424a0 .
ISSN
0028-0836 .
PMID
7760939 .
S2CID
4338992 .
^ Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature , 391, 199-203.
^ Nogales, E.; Whittaker, M.; Milligan, R. A.; Downing, K. H. (1999-01-08).
"High-resolution model of the microtubule" . Cell . 96 (1): 79–88.
doi :
10.1016/s0092-8674(00)80961-7 .
ISSN
0092-8674 .
PMID
9989499 .
S2CID
18422680 .
^ Callaway, Ewen (2015-09-10).
"The revolution will not be crystallized: a new method sweeps through structural biology" . Nature . 525 (7568): 172–174.
Bibcode :
2015Natur.525..172C .
doi :
10.1038/525172a .
ISSN
1476-4687 .
PMID
26354465 .
^ Downing, Kenneth H.; Nogales, Eva (2010). Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors . Methods in Enzymology. Vol. 483. pp. 121–142.
doi :
10.1016/S0076-6879(10)83006-X .
ISBN
9780123849939 .
ISSN
1557-7988 .
PMC
4165512 .
PMID
20888472 .
^ Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell , 152(1):120–131.
^
"Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery" . GEN – Genetic Engineering and Biotechnology News . 2018-11-20. Retrieved 2019-03-23 .
^
"The 3D Structure of Telomerase: Uncovering Its Role in Human Disease" . Drug Discovery from Technology Networks . Retrieved 2019-03-23 .
^
"Early Career Life Scientist Award" . ASCB . Retrieved 2019-03-23 .
^
"Announcing the winners of the 2015 Protein Society Awards" . EurekAlert! . Retrieved 2019-03-23 .
^
"Eva Nogales" . nasonline.org . 16 April 2021. Retrieved 29 December 2023 .
^
"9 campus faculty selected for membership in American Academy of Arts and Sciences | The Daily Californian" . The Daily Californian . 2016-04-22. Retrieved 2018-02-03 .
^
"Women in Cell Biology Awards" . ASCB . Retrieved 2019-03-23 .
^
"Nogales Receives 2019 Grimwade Medal" . Biosciences Area . 2019-03-07. Retrieved 2019-03-23 .
^
"AAAS Honors Outstanding Scientific Contributors as 2021 AAAS Fellows | American Association for the Advancement of Science" . www.aaas.org . Retrieved 2022-03-16 .
^
Shaw Prize 2023
^ Phelan, Laura (1 December 2014).
"Eva Nogales" . The
Biophysical Society . Retrieved 29 December 2023 .
External links
Astronomy Life science and medicine Mathematical science
International National Academics