American cell biologist
Scott D. Emr (born February 8, 1954) is an American
cell biologist and the founding and current Director of the
Weill Institute for Cell and Molecular Biology at
Cornell University , where he is also a
Frank H.T. Rhodes Class of 1956 Professor at the Department of Molecular Biology and Genetics.
[5]
Early life and education
Emr was born in
Jersey City
[1] and grew up in
Fort Lee, New Jersey . His father was a manager of a manufacturing company. He has a sister and two brothers.
[4]
The 1960s documentary
The Undersea World of Jacques Cousteau prompted him to pick a
university with a strong
oceanography program, starting in 1972 at the
University of Rhode Island as a
biology major. He became interested in
genetics during his
undergraduate years.
[4] He started his
PhD in 1976 at the Department of Microbiology and Molecular Genetics at
Harvard University , working under
Thomas Silhavy and
Jonathan Beckwith and graduating in 1981.
[3]
[4]
Career
Emr began his career at the
University of California, Berkeley as a
Miller Institute Fellow
[6] and a
postdoctoral researcher at
Randy Schekman 's group.
[4] He moved to the
California Institute of Technology in 1983, becoming an
assistant , and later
associate professor , at the Division of Biology.
[3]
George Emil Palade recruited Emr to the
University of California, San Diego in 1991,
[4] where he stayed as a Distinguished Professor at the Department of Cellular and Molecular Medicine and, at the same time, an investigator at the
Howard Hughes Medical Institute .
[7] He left for
Cornell University in 2007 when he was appointed as the founding director of the Institute of Cell and Molecular Biology (later renamed to
Weill Institute for Cell and Molecular Biology after a donation from Joan and
Sanford I. Weill )
[8] and a
Frank H.T. Rhodes Class of 1956 Professor at the Department of Molecular Biology and Genetics.
[3]
[9]
Academically, Emr serves on the editorial boards of several scientific journals, including (as of 2021)
mBio ,
[10]
Journal of Cell Biology ,
[11]
Trends in Cell Biology ,
[12] and
Current Opinion in Cell Biology .
[13]
Research
Emr's research focuses on the regulation of
membrane vesicle trafficking pathways. His lab's study of the
ESCRT (endosomal sorting complexes required for transport) complexes earned him a
Shaw Prize in Life Science and Medicine.
[14] ESCRTs are required for the degradation of
membrane protein at the
lysosome , a late step in
cytokinesis , and the budding and release of
human immunodeficiency virus (HIV).
[3]
[5]
[15]
[16]
His other research interests include
lipid signaling (especially a group of lipids known as
phosphatidylinositol phosphates ),
[17]
protein
transport in cells by
vesicles
[18] and the role of
arrestin and
ubiquitylation in the degradation of membrane proteins.
[3]
[5]
[19]
Honors and awards
Personal life
Emr met his wife Michelle in his
junior year at university. She was also in her third year, majoring in
music and
early education . They married three years later when Emr was pursuing his
PhD . As of 2021, their daughter Bryanna is a
pediatric surgeon in
Pittsburgh , and their son Kevin is an
anesthesiologist in
Albany, New York .
[4]
References
^
a
b
c
d
"Scott D Emr" .
The Shaw Prize Foundation . June 1, 2021. Archived from
the original on November 6, 2021. Retrieved November 6, 2021 .
^ Emr, Scott David (1981).
Protein localization in Escherichia coli (PhD).
Harvard University . Retrieved November 6, 2021 .
^
a
b
c
d
e
f
"BIOGRAPHICAL SKETCH" (PDF) .
Cornell University . 2017. Archived from
the original (PDF) on November 6, 2021. Retrieved November 6, 2021 .
^
a
b
c
d
e
f
g
h
"Autobiography of Scott D Emr" . The Shaw Prize Foundation. Archived from
the original on November 6, 2021. Retrieved November 6, 2021 .
^
a
b
c
"The Emr Lab" . Cornell University. Archived from
the original on November 8, 2021. Retrieved November 8, 2021 .
^
"All Miller Fellows: By Name" .
University of California, Berkeley . Archived from
the original on November 12, 2021. Retrieved November 12, 2021 .
^
"Scott D. Emr, PhD" .
Howard Hughes Medical Institute . Archived from
the original on November 16, 2021. Retrieved November 16, 2021 .
^ Ramanujan, Krishna (June 13, 2007).
"Institute for Cell and Molecular Biology benefits from $25 million gift from the Weills" .
Cornell Chronicle . Archived from
the original on November 15, 2021. Retrieved November 15, 2021 .
^ Ramanujan, Krishna (May 24, 2006).
"A major hire to advance and extend life sciences at Cornell" . Cornell Chronicle . Archived from
the original on November 16, 2021. Retrieved November 16, 2021 .
^
"mBio Board of Editors" .
mBio . Archived from
the original on November 19, 2021. Retrieved November 19, 2021 .
^
"Editorial Board" .
Journal of Cell Biology . Archived from
the original on August 14, 2021. Retrieved November 23, 2021 .
^
"Advisory board" .
Trends in Cell Biology . Archived from
the original on November 23, 2021. Retrieved November 23, 2021 .
^
"Editorial Board" .
Current Opinion in Cell Biology . Archived from
the original on November 23, 2021. Retrieved November 23, 2021 .
^
"Press Release" (Press release). The Shaw Prize Foundation. June 1, 2021. Archived from
the original on November 24, 2021. Retrieved November 24, 2021 .
^ Katzmann, David J.; Babst, Markus; Emr, Scott D. (2001).
"Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I" .
Cell . 106 (2): 145–155.
doi :
10.1016/S0092-8674(01)00434-2 .
PMID
11511343 .
^ Banjade, Sudeep; Tsang, Shaogeng; Shah, Yousuf H; Emr, Scott D (2019).
"Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly" .
eLife . 8 : e46207.
doi :
10.7554/eLife.46207 .
PMC
6663469 .
PMID
31246173 .
^ Burd, Christopher G; Emr, Scott D (1998).
"Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains" .
Molecular Cell . 2 (1): 157–162.
doi :
10.1016/S1097-2765(00)80125-2 .
PMID
9702203 .
^ Suzuki, Sho W.; Emr, Scott D. (2018).
"Membrane protein recycling from the vacuole/lysosome membrane" .
Journal of Cell Biology . 217 (5): 1623–1632.
doi :
10.1083/jcb.201709162 .
PMC
5940307 .
PMID
29511122 . Archived from
the original on November 29, 2021. Retrieved November 29, 2021 .
^ Lin, Charles H.; MacGurn, Jason A.; Chu, Tony; Stefan, Christopher J.; Emr, Scott D. (2008).
"Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface" . Cell . 135 (4): 714–725.
doi :
10.1016/j.cell.2008.09.025 .
PMID
18976803 .
^
a
b Spiro, Mary (September 22, 2017).
"Cornell's Scott D. Emr to deliver 2017 Porter Lecture" (Press release).
American Society for Cell Biology . Archived from
the original on June 8, 2021. Retrieved June 8, 2021 .
^
"Elected Fellows" .
American Association for the Advancement of Science . Archived from
the original on November 19, 2021. Retrieved November 19, 2021 .
^
"Scott D. Emr" .
American Academy of Arts and Sciences . Archived from
the original on November 22, 2021. Retrieved November 22, 2021 .
^
"Scott D. Emr" .
National Academy of Sciences . Archived from
the original on June 2, 2019. Retrieved November 19, 2021 .
^
"72 new members chosen by academy" .
EurekAlert! . May 1, 2007. Archived from
the original on November 19, 2021. Retrieved November 19, 2021 .
^
"Avanti Award in Lipids" .
American Society for Biochemistry and Molecular Biology . Archived from
the original on November 21, 2021. Retrieved November 21, 2021 .
^
"Scott D. Emr" .
European Molecular Biology Organization . Archived from
the original on November 21, 2021. Retrieved November 21, 2021 .
^ Ramanujan, Krishna (October 16, 2008).
"Emr elected associate member of elite European Molecular Biology Organization" . Cornell Chronicle . Archived from
the original on November 22, 2021. Retrieved November 22, 2021 .
^
"Van Deenen Medal" . Institute of Biomembranes,
Utrecht University . Archived from
the original on November 9, 2021. Retrieved November 21, 2021 .
^
"Keith R. Porter Lecture" .
American Society for Cell Biology . Archived from
the original on November 22, 2021. Retrieved November 22, 2021 .
^
"Scott Emr" . American Society for Cell Biology. Archived from
the original on November 22, 2021. Retrieved November 22, 2021 .
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