From Wikipedia, the free encyclopedia
Dihydrokainic acid
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Names
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IUPAC name
(3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline
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Systematic IUPAC name
(2S,3S,4R)-3-(2-Hydroxy-2-oxoethyl)-4-(propan-2-yl)pyrrolidine-2-carboxylic acid
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Other names
Dihydrokainate; DHK
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Identifiers
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84942
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ChEBI
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ChEMBL
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ChemSpider
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UNII
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InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 Key: JQPDCKOQOOQUSC-OOZYFLPDSA-N
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CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
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Properties
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C10H17NO4
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Molar mass
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215.249 g·mol−1
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Hazards
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GHS labelling:
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Warning
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H302,
H312,
H332
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P261,
P264,
P270,
P271,
P280,
P301+P312,
P302+P352,
P304+P312,
P304+P340,
P312,
P322,
P330,
P363,
P501
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Dihydrokainic acid is an
organic compound that contains two
carboxylic acid functional groups, making it a
dicarboxylic acid. It is an inhibitor of the
GLT-1 glutamate transporter.
[1]
See also
References
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^ Kawahara, K; Hosoya, R; Sato, H; Tanaka, M; Nakajima, T; Iwabuchi, S (2002). "Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures". Glia. 40 (3): 337–49.
doi:
10.1002/glia.10133.
hdl:
2115/5937.
PMID
12420313.
S2CID
14246291.
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Transporter |
EAATsTooltip Excitatory amino acid transporters | |
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vGluTsTooltip Vesicular glutamate transporters | |
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Enzyme |
GAHTooltip Glutamine aminohydrolase (glutaminase) | |
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ASTTooltip Aspartate aminotransferase | |
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ALTTooltip Alanine aminotransferase | |
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GDHTooltip Glutamate dehydrogenase | |
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GSTooltip Glutamine synthetase | |
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GADTooltip Glutamate decarboxylase | |
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