ctgf/hcs24 CAESAR | |
---|---|
Identifiers | |
Symbol | CAESAR |
Rfam | RF00172 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Eukaryota |
SO | SO:0000233 |
PDB structures | PDBe |
ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor ( CTGF) messenger RNA. [1] This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).
The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised [1] and subsequently the minimal RNA element responsible for repression was identified [2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).
The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression. [3]