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Investigational new anti-HIV drug
Censavudine
Other names 4'-ethynylstavudine, festinavir
Legal status
1-[(2R ,5R )-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methylpyrimidine-2,4-dione
CAS Number
PubChem
CID
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
CompTox Dashboard (
EPA )
ECHA InfoCard
100.225.812
Formula C 12 H 12 N 2 O 4
Molar mass 248.238 g·mol−1 3D model (
JSmol )
CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@](O2)(CO)C#C
InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1
Key:OSYWBJSVKUFFSU-SKDRFNHKSA-N
Censavudine (
INN ;
[1] development code BMS-986001 ) is an
investigational new drug being developed by
Bristol Myers-Squibb for the treatment of
HIV infection.
[2]
[3] It was originally developed at
Yale University .
[4] It is still in an investigational phase of development as of 2023.
[5]
Renaming
Until 2013, censavudine has been known as festinavir , but the name was changed to avoid confusion with HIV
protease inhibitors which all bear class suffix "–navir" (e.g.
tipranavir ,
lopinavir ,
saquinavir , etc.).
[5]
References
^
"International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed International Nonproprietary Names: List 110" (PDF) . World Health Organization. pp. 409–410.
^ Wu VH, Smith RA, Masoum S, Raugi DN, Ba S, Seydi M, et al. (August 2017).
"MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture" . Antimicrobial Agents and Chemotherapy . 61 (8).
doi :
10.1128/AAC.00744-17 .
PMC
5527656 .
PMID
28559249 .
^ Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, et al. (January 2016). "Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial". The Lancet. HIV . 3 (1): e13-22.
doi :
10.1016/S2352-3018(15)00231-3 .
hdl :
1805/10552 .
PMID
26762988 .
^ Alcorn K (21 December 2010).
"Bristol-Myers Squibb buys festinavir, new NRTI active against MDR HIV" . aidsmap.com .
aidsmap . Retrieved 24 June 2011 .
^
a
b PubChem.
"Censavudine" . pubchem.ncbi.nlm.nih.gov . Retrieved 2023-10-24 .