From Wikipedia, the free encyclopedia
Caspase-2 (
EC
3.4.22.55 , ICH-1 , NEDD-2 , caspase-2L , caspase-2S , neural precursor cell expressed developmentally down-regulated protein 2 , CASP-2 , NEDD2 protein ) is an
enzyme .
[1]
[2]
[3]
[4]
[5]
[6] This enzyme
catalyses the following
chemical reaction
Strict requirement for an Asp residue at P1, with Asp316 being essential for
proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
Caspase-2 is an initiator
caspase , as are caspase-8 (
EC 3.4.22.61 ), caspase-9 (
EC 3.4.22.62 ) and caspase-10 (
EC 3.4.22.63 ).
References
^ Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (July 1994).
"Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme" . Genes & Development . 8 (14): 1613–26.
doi :
10.1101/gad.8.14.1613 .
PMID
7958843 .
^ Wang L, Miura M, Bergeron L, Zhu H, Yuan J (September 1994). "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell . 78 (5): 739–50.
doi :
10.1016/S0092-8674(94)90422-7 .
PMID
8087842 .
^ Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J (August 1997).
"Activation of caspase-2 in apoptosis" . The Journal of Biological Chemistry . 272 (34): 21010–7.
doi :
10.1074/jbc.272.34.21010 .
PMID
9261102 .
^ Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A (May 2000).
"Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis" . The Journal of Cell Biology . 149 (3): 603–12.
doi :
10.1083/jcb.149.3.603 .
PMC
2174848 .
PMID
10791974 .
^ Zhivotovsky B, Orrenius S (June 2005).
"Caspase-2 function in response to DNA damage" . Biochemical and Biophysical Research Communications . 331 (3): 859–67.
doi :
10.1016/j.bbrc.2005.03.191 .
PMID
15865942 .
^
Chang HY , Yang X (December 2000).
"Proteases for cell suicide: functions and regulation of caspases" . Microbiology and Molecular Biology Reviews . 64 (4): 821–46.
doi :
10.1128/mmbr.64.4.821-846.2000 .
PMC
99015 .
PMID
11104820 .
External links
Activity Regulation Classification Kinetics Types