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Protein-coding gene in humans
Cytoplasmic polyadenylation element-binding protein 1 is a
protein that in
humans is encoded by the CPEB1
gene .
[5]
[6]
This gene encodes a member of the
cytoplasmic polyadenylation element (CPE) binding
protein family . This highly conserved protein binds to a specific
RNA sequence called the CPE found in the 3' UTR of some
mRNAs . Similar proteins in
Xenopus and
mouse function to induce
cytoplasmic
polyadenylation of dormant mRNAs with short polyA tails, resulting in their
translation . Members of this protein family regulate translation of
cyclin B1 during
embryonic
cell divisions . Multiple
transcript
variants encoding different
isoforms have been found for this gene.
[6]
References
Further reading
Mendez R, Richter JD (2001).
"Translational control by CPEB: a means to the end" . Nat. Rev. Mol. Cell Biol . 2 (7): 521–9.
doi :
10.1038/35080081 .
PMID
11433366 .
S2CID
815958 .
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999).
"Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108.
doi :
10.1101/gr.8.11.1097 .
PMID
9847074 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Huang YS, Carson JH, Barbarese E, Richter JD (2003).
"Facilitation of dendritic mRNA transport by CPEB" . Genes Dev . 17 (5): 638–53.
doi :
10.1101/gad.1053003 .
PMC
196011 .
PMID
12629046 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wilczynska A, Aigueperse C, Kress M, et al. (2005).
"The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules" . J. Cell Sci . 118 (Pt 5): 981–92.
doi :
10.1242/jcs.01692 .
PMID
15731006 .
Sasayama T, Marumoto T, Kunitoku N, et al. (2005).
"Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1" . Genes Cells . 10 (7): 627–38.
doi :
10.1111/j.1365-2443.2005.00870.x .
hdl :
20.500.14094/D2002840 .
PMID
15966895 .
S2CID
24879593 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
External links