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Class of enzymes
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (
EC
3.7.1.14 , mhpC (gene) ) is an
enzyme with
systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase .
[1]
[2]
[3]
[4]
[5]
[6] This enzyme
catalyses the following
chemical reaction :
(2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2 O
⇌
{\displaystyle \rightleftharpoons }
(2Z)-2-hydroxypenta-2,4-dienoate +
succinate
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2 O
⇌
{\displaystyle \rightleftharpoons }
(2Z)-2-hydroxypenta-2,4-dienoate +
fumarate
This enzyme catalyses a step in a pathway of
phenylpropanoid compounds degradation.
References
^ Burlingame R, Chapman PJ (July 1983).
"Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli" . Journal of Bacteriology . 155 (1): 113–21.
PMC
217659 .
PMID
6345502 .
^ Burlingame RP, Wyman L, Chapman PJ (October 1986).
"Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation" . Journal of Bacteriology . 168 (1): 55–64.
PMC
213419 .
PMID
3531186 .
^ Lam WW, Bugg TD (1994). "Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic cleavage". J. Chem. Soc., Chem. Commun . 10 (10): 1163–1164.
doi :
10.1039/c39940001163 .
^ Lam WW, Bugg TD (October 1997). "Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase". Biochemistry . 36 (40): 12242–51.
doi :
10.1021/bi971115r .
PMID
9315862 .
^ Ferrández A, Garciá JL, Díaz E (April 1997).
"Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12" . Journal of Bacteriology . 179 (8): 2573–81.
PMC
179006 .
PMID
9098055 .
^ Díaz E, Ferrández A, García JL (June 1998).
"Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12" . Journal of Bacteriology . 180 (11): 2915–23.
PMC
107259 .
PMID
9603882 .
External links
Activity Regulation Classification Kinetics Types