|Tupelo High School|
4125 Golden Wave Drive
Tupelo, Mississippi 38801
|Coordinates||US_type:edu 34°13′55″N 88°45′50″W / 34.232°N 88.764°W|
|School district||Tupelo Public School District|
|Faculty||108.87 (on FTE basis) |
|Grades||9 to 12|
|Enrollment||1,930  (2019–20)|
|Student to teacher ratio||17.73 |
|Color(s)||Blue and Gold|
|Accreditation||Southern Association of Colleges and Schools |
|Newspaper||The Hi-Times |
Tupelo High School is the only public high school in Tupelo, Mississippi. The campus consists of fourteen buildings, including a Performing Arts Center, separate buildings for social studies, English, math, sciences, fine arts, and a self-contained grade-9 building. The current student population of the school is about 1,995. As of 2014–2015, it is the largest enrolled public high school in the state of Mississippi. The class of 2015 consisted of 438 graduates. The school offers a curriculum containing 160 Carnegie units, 24 of which are Advanced Placement.
Tupelo High School is a two-time National Blue Ribbon School award winner, having won the award in 1983-1984 and another in 1999–2000. 
The school's boundary includes the vast majority of Tupelo and a portion of Saltillo. 
As of 2022- 2023, Tupelo High School offers extracurricular activities, including football, slowpitch and fastpitch softball, cross country, volleyball, swimming, basketball, soccer, bowling, archery, baseball, wrestling, golf, tennis, cheer, and track and field. In addition to athletics, the school offers other clubs, such as theatre, a school newspaper, arts, and mock trials.