From Wikipedia, the free encyclopedia
Taiwanese chemist
This article is about the chemist. For the visual artist, see
Lin Yushan .
Yu-Shan Lin is a computational chemist. She is an associate professor of chemistry at
Tufts University in the United States.
[1] Her research lab uses
computational chemistry to understand and design
biomolecules , with topics focusing on
cyclic peptides ,
[2]
[3]
protein folding ,
[4]
[5] and
collagen .
[6]
[7]
Education
Lin received her BS in chemistry from
National Taiwan University in 2004.
[8] Lin received her PhD in chemistry in 2009 from
University of Wisconsin, Madison , under the guidance of
James L. Skinner .
[9] She then moved to
Stanford , where she was a Bio-X postdoctoral fellow in the lab of
Vijay S. Pande .
[10] In 2012, Lin joined the Department of Chemistry at
Tufts University and received tenure in 2018.
[8]
Research
Cyclic peptides
Lin and her lab use
computational chemistry to provide information on the solution structures of
cyclic peptides .
[2] They recently successfully used
molecular dynamics simulation with enhanced sampling methods to design well-structured cyclic peptides.
[11]
[12]
Protein folding
Lin and her lab are interested in understanding how co- and post-translational modifications and non-natural
amino acids impact protein folding.
[13]
[14] They also work on understanding the effects of amino acid substitutions during evolution on protein stability,
folding , and interaction.
[15]
[16]
Collagen
Lin and her lab use molecular dynamics simulations to understand how the structure, stability, and interactions of collagen are perturbed by Gly to Ser substitutions, a very common type of Gly missense mutations in patients with
Osteogenesis Imperfecta (OI),
[17]
[18]
[19] and Ser phosphorylation.
[20] Their results suggest a new possible mechanism underlying OI pathology, specifically that mutations may significantly disrupt the
triple-helical structure of collagen and render it susceptible to non-collagenase proteolytic enzymes.
[18]
Awards and honors
Machine Learning in the Chemical Sciences & Engineering Award, Camille and Henry Dreyfus Foundation, 2020
[21]
2015: OpenEye Outstanding Junior Faculty Award in Computational Chemistry,
[22]
American Chemical Society
References
^
"Faculty | Department of Chemistry" . chem.tufts.edu . Retrieved July 13, 2021 .
^
a
b Damjanovic, Jovan; Miao, Jiayuan; Huang, He; Lin, Yu-Shan (February 24, 2021).
"Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations" . Chemical Reviews . 121 (4): 2292–2324.
doi :
10.1021/acs.chemrev.0c01087 .
ISSN
0009-2665 .
PMC
8340081 .
PMID
33426882 .
^
"c&en: Cross-Linking Technique Could Complement Peptide Stapling, April 29, 2013" .
^ Mong, Surin K.; Cochran, Frank V.; Yu, Hongtao; Graziano, Zachary; Lin, Yu-Shan;
Cochran, Jennifer R. ; Pentelute, Bradley L. (October 31, 2017).
"Heterochiral Knottin Protein: Folding and Solution Structure" . Biochemistry . 56 (43): 5720–5725.
doi :
10.1021/acs.biochem.7b00722 .
ISSN
0006-2960 .
PMC
5818992 .
PMID
28952732 .
^
"Biochemists discover mechanism that helps flu viruses evolve" . MIT News | Massachusetts Institute of Technology . Retrieved July 13, 2021 .
^ An, Bo; Lin, Yu-Shan; Brodsky, Barbara (February 1, 2016).
"Collagen interactions: Drug design and delivery" . Advanced Drug Delivery Reviews . 97 : 69–84.
doi :
10.1016/j.addr.2015.11.013 .
ISSN
0169-409X .
PMID
26631222 .
^ Chen, Eric A.; Lin, Yu-Shan (November 1, 2019).
"Using synthetic peptides and recombinant collagen to understand DDR–collagen interactions" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1866 (11): 118458.
doi :
10.1016/j.bbamcr.2019.03.005 .
ISSN
0167-4889 .
PMID
30880148 .
^
a
b
"Yu-Shan Lin | YSL at Tufts" . ase.tufts.edu . Retrieved July 13, 2021 .
^
"Chemistry Tree - James L. Skinner Family Tree" . academictree.org . Retrieved July 13, 2021 .
^ University, © Stanford; Stanford; California 94305 (March 7, 2014).
"Yu-Shan Lin - Bio-X Postdoctoral Fellow" . Welcome to Bio-X . Retrieved July 11, 2021 . {{
cite web }}
: CS1 maint: numeric names: authors list (
link )
^ Slough, Diana P.; McHugh, Sean M.; Cummings, Ashleigh E.; Dai, Peng; Pentelute, Bradley L.; Kritzer, Joshua A.; Lin, Yu-Shan (March 28, 2018).
"Designing Well-Structured Cyclic Pentapeptides Based on Sequence–Structure Relationships" . The Journal of Physical Chemistry B . 122 (14): 3908–3919.
doi :
10.1021/acs.jpcb.8b01747 .
ISSN
1520-6106 .
PMC
6071411 .
PMID
29589926 .
^ Cummings, Ashleigh E.; Miao, Jiayuan; Slough, Diana P.; McHugh, Sean M.; Kritzer, Joshua A.; Lin, Yu-Shan (February 5, 2019).
"β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides" . Biophysical Journal . 116 (3): 433–444.
Bibcode :
2019BpJ...116..433C .
doi :
10.1016/j.bpj.2018.12.015 .
ISSN
0006-3495 .
PMC
6369414 .
PMID
30661666 .
^ Rogers, Julia R.; McHugh, Sean M.; Lin, Yu-Shan (September 27, 2017).
"Predictions for α-Helical Glycopeptide Design from Structural Bioinformatics Analysis" . Journal of Chemical Information and Modeling . 57 (10): 2598–2611.
doi :
10.1021/acs.jcim.7b00123 .
ISSN
1549-9596 .
PMID
28953376 .
^ Simon, Mark D.; Maki, Yuta; Vinogradov, Alexander A.; Zhang, Chi; Yu, Hongtao; Lin, Yu-Shan; Kajihara, Yasuhiro; Pentelute, Bradley L. (September 21, 2016).
"d-Amino Acid Scan of Two Small Proteins" . Journal of the American Chemical Society . 138 (37): 12099–12111.
doi :
10.1021/jacs.6b03765 .
ISSN
0002-7863 .
PMID
27494078 .
^ Phillips, Angela M; Gonzalez, Luna O; Nekongo, Emmanuel E; Ponomarenko, Anna I; McHugh, Sean M; Butty, Vincent L; Levine, Stuart S; Lin, Yu-Shan; Mirny, Leonid A; Shoulders, Matthew D (September 26, 2017). Palese, Peter (ed.).
"Host proteostasis modulates influenza evolution" . eLife . 6 : e28652.
doi :
10.7554/eLife.28652 .
ISSN
2050-084X .
PMC
5614556 .
PMID
28949290 .
^ Phillips, Angela M.; Ponomarenko, Anna I.; Chen, Kenny; Ashenberg, Orr; Miao, Jiayuan; McHugh, Sean M.; Butty, Vincent L.; Whittaker, Charles A.; Moore, Christopher L.; Bloom, Jesse D.; Lin, Yu-Shan (September 17, 2018).
"Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones" . PLOS Biology . 16 (9): e3000008.
doi :
10.1371/journal.pbio.3000008 .
ISSN
1545-7885 .
PMC
6160216 .
PMID
30222731 .
^ Yigit, Sezin; Yu, Hongtao; An, Bo; Hamaia, Samir; Farndale, Richard W.; Kaplan, David L.; Lin, Yu-Shan; Brodsky, Barbara (September 2, 2016).
"Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding *" . Journal of Biological Chemistry . 291 (36): 19196–19207.
doi :
10.1074/jbc.M116.726182 .
ISSN
0021-9258 .
PMC
5009287 .
PMID
27432884 .
^
a
b Chhum, Panharith; Yu, Hongtao; An, Bo; Doyon, Brian R.; Lin, Yu-Shan; Brodsky, Barbara (December 1, 2016).
"Consequences of Glycine Mutations in the Fibronectin-binding Sequence of Collagen *" . Journal of Biological Chemistry . 291 (53): 27073–27086.
doi :
10.1074/jbc.M116.753566 .
ISSN
0021-9258 .
PMC
5207138 .
PMID
27799304 .
^ Qiu, Yimin; Mekkat, Arya; Yu, Hongtao; Yigit, Sezin; Hamaia, Samir; Farndale, Richard W.;
Kaplan, David L. ; Lin, Yu-Shan; Brodsky, Barbara (September 1, 2018).
"Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding" . Journal of Structural Biology . 203 (3): 255–262.
doi :
10.1016/j.jsb.2018.05.003 .
ISSN
1047-8477 .
PMC
6089640 .
PMID
29758270 .
^ Qiu, Yimin; Poppleton, Erik; Mekkat, Arya; Yu, Hongtao; Banerjee, Sourav; Wiley, Sandra E.; Dixon, Jack E.; Kaplan, David L.; Lin, Yu-Shan; Brodsky, Barbara (December 18, 2018).
"Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide" . Biophysical Journal . 115 (12): 2327–2335.
Bibcode :
2018BpJ...115.2327Q .
doi :
10.1016/j.bpj.2018.11.012 .
ISSN
0006-3495 .
PMC
6302033 .
PMID
30527445 .
^ Moderator (July 27, 2020).
"Dreyfus Program for Machine Learning in the Chemical Sciences & Engineering Awards" . Dreyfus Foundation . Retrieved August 15, 2023 .
^
"OpenEye Outstanding Junior Faculty Award in Computational Chemistry" . www.acscomp.org . Retrieved July 11, 2021 .
External links