DeRisi was raised in Carmichael, California, where he graduated from Del Campo High School. [1] He became interested in the causes of disease in the 1980s as a teenager, seeing news coverage about the AIDS epidemic and scientists' attempts to identify the cause of illness and deaths. [2] He received a B.A. in Biochemistry and Molecular Biology in 1992 from the University of California, Santa Cruz. [3]
DeRisi earned his Ph.D. in Biochemistry from Stanford University in 1999. [3] His thesis work was The Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae. [4] He completed his Ph.D. research in the laboratory of Patrick O. Brown, where he pioneered methods for the production and use of DNA microarrays. [5] [6] Upon graduation, DeRisi accepted a position as a Sandler Fellow at the University of California San Francisco (UCSF). [3] [7]