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Mr. Ibrahem/Estropipate
Clinical data
Trade namesHarmogen, Improvera, Ogen, Ortho-Est, Sulestrex, others
Other namesPiperazine estrone sulfate; [1] Estrone sulfate piperazine salt; Pipestrone
AHFS/ Drugs.com Monograph
Routes of
administration		 By mouth
Drug class Estrogen
Identifiers
  • [(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; piperazine
Chemical and physical data
FormulaC22H32N2O5S
Molar mass436.57 g·mol−1
3D model ( JSmol)
  • O=S(=O)(O)Oc1cc4c(cc1)[C@@H]3[C@H]([C@@H]2CCC(=O)[C@@]2(C)CC3)CC4.N1CCNCC1
  • InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1 checkY
  • Key:HZEQBCVBILBTEP-ZFINNJDLSA-N checkY
   (verify)

Estropipate, sold under the brand name Ogen among others, is a medication used to treat the symptoms of menopause and ovarian failure. [1] It was previously also used to prevent postmenopausal osteoporosis. [1] It is taken by mouth. [1]

Common side effects include headache, breast pain, irregular vaginal bleeding, abdominal cramps, and nausea. [1] Other side effects may include high blood pressure, liver problems, high sugar, swelling, hair loss, and vaginal yeast infections. [1] Rarely blood clots or gallbladder disease may occur. [1] It is an estrogen, specifically a salt of estrone sulfate and piperazine, which is transformed into estrone and estradiol in the body. [2] [3]

Estropipate was first made commercially in the United States in 1950. [4] In the United States 100 tablets of 0.75 mg used to cost about 50 USD. [5] Production; however, has been discontinued in the United States as of 2021. [6] [7]

References

  1. ^ a b c d e f g h i "DailyMed - ESTROPIPATE tablet". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 17 December 2021.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 900–. ISBN  978-1-4757-2085-3. Archived from the original on 27 June 2021. Retrieved 19 October 2020.
  3. ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 114–. ISBN  978-94-011-4439-1.
  4. ^ Report on Carcinogens: Carcinogen Profiles. Department of Health and Human Services, Public Health Service, National Toxicology Program. 2000. p. RA1-PA26. Archived from the original on 2022-01-11. Retrieved 2021-12-17.
  5. ^ "Estropipate Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 17 December 2021.
  6. ^ "Estropipate Prices and Estropipate Coupons - GoodRx". GoodRx. Retrieved 17 December 2021.
  7. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Archived from the original on 22 March 2021. Retrieved 19 December 2021.
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