University of Texas Southwestern Medical Center
|Type||Public medical school|
|Endowment||$1.82 billion (2017) |
|Budget||$3.4 billion (2020) |
|President||Daniel K. Podolsky, M.D.|
|Dean||Wei-Ping Lee, M.D.|
|3691 (1,394 full-time, 402 part-time, 1,755 voluntary, 110 faculty associates, and 30 administrators)|
Latitude and Longitude:
|Campus||Urban, 231 acres (0.9 km2)|
The University of Texas Southwestern Medical Center (UT Southwestern or UTSW) is a public academic health science center in Dallas, Texas. With approximately 13,568 employees and 2,445 faculty and over 2.7 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and state of Texas. 
UT Southwestern's operating budget in 2019 was more than $3.152 billion,  and is the largest medical institution in the Dallas–Fort Worth metroplex (and therefore North Texas region), annually training about 3,700 medical, graduate, and health professions students, residents, and postdoctoral fellows. Ongoing support from outside sources provides approximately $422.6 million per year for more than 5,700 research projects. In 2017, the school had the largest federal expenditure funding of all UT System medical institutions at $204.5 million. 
UT Southwestern's three-part mission is to: educate leaders in patient care, biomedical science, and disease prevention; conduct research; and deliver patient care. It incorporates three major degree-granting institutions – UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, and UT Southwestern School of Health Professions. UT Southwestern has four major affiliated hospitals: Parkland Memorial Hospital, Children's Medical Center, Zale Lipshy Pavilion – William P. Clements Jr. University Hospital, and William P. Clements Jr. University Hospital. However UT Southwestern's faculty also provide services at Texas Scottish Rite Hospital for Children, VA North Texas Health Care System, and other affiliated hospitals and community clinics in the North Texas region. Faculty and residents care for more than 100,000 hospitalized patients and oversee approximately 2.2 million outpatient visits a year, including more than $106.7 million in unreimbursed clinical services annually.
Through the four major hospitals affiliated with UT Southwestern, the medical center also has a large presence in Plano and Frisco, prominent suburbs in the Dallas area. Furthermore, in 2016, UT Southwestern began providing additional care through Southwestern Health Resources, a new network combining the systems of Texas Health Resources and UT Southwestern. The network comprises 27 hospitals, 300 clinics, and more than 2,000 physicians, serving a 16-county area with more than 6 million residents.
Under the leadership of Dr. Edward H. Cary and Karl Hoblitzelle, a group of Dallas citizens organized Southwestern Medical Foundation in 1939 to promote medical education and research in Dallas and the region. When Baylor University moved its school of medicine from Dallas to Houston in 1943, the foundation formally established Southwestern Medical College as the 68th medical school in the United States. Founded during World War II, the medical school was initially housed in a handful of abandoned barracks.
When a new state medical school was proposed after World War II, leaders of Southwestern Medical Foundation offered the college's equipment, library, and certain restricted funds to the University of Texas System, provided the university would locate its new medical branch in Dallas. The Board of Regents accepted this offer, and in 1949 the college became Southwestern Medical School of The University of Texas. In 1954 the name was changed to The University of Texas Southwestern Medical School. The present campus site on Harry Hines Boulevard was occupied in 1955 upon the completion of the Edward H. Cary Building. This placed the medical school faculty next to the then-newly built Parkland Memorial Hospital.
In November 1972 the name and scope of the medical school were changed with its reorganization into The University of Texas Health Science Center at Dallas. This provided for coordinated but separate medical, graduate, and undergraduate components.
In 1986 the Howard Hughes Medical Institute opened a research facility on the campus. Its investigators also hold faculty positions in the basic science departments of the Medical School and Graduate School.
In October 1987 the UT System Board of Regents approved changing the name of the health science center to The University of Texas Southwestern Medical Center at Dallas. The Center consists of three degree-granting institutions: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, and UT Southwestern School of Health Professions.
Since the late 1960s the university has added more than 6 million square feet of new construction. The 60-acre South Campus includes 20 buildings housing classrooms, laboratories, offices, the extensive University of Texas Southwestern Medical Center Library, an auditorium, and a large outpatient center. Affiliated hospitals adjacent to the campus are Zale Lipshy Pavilion, Parkland Memorial Hospital, William P. Clements Jr. University Hospital, and Children's Medical Center (Dallas).
In 1987 the John D. and Catherine T. MacArthur Foundation gave the university 30 acres (120,000 m2) near the South Campus for future expansion. A 20-year master plan for the site, called North Campus, called for six research towers, a support-services building, an energy plant, and underground parking, in addition to the Mary Nell and Ralph B. Rogers Magnetic Resonance Center and the Moncrief Radiation Oncology Center. Three research towers and an elevated campus connector, linking the South Campus with the North Campus, were completed in the 1990s. A fourth 14-story research tower was completed in 2005, followed by a 12-story research tower in 2011. In 1999 the university purchased an additional 50 acres from the MacArthur Foundation, and a portion was used to create an on-campus student-housing complex of 156 apartments. A second phase of 126 units opened in 2004. In 2008, the university purchased the 24-acre Exchange Park adjacent to the North Campus.
In 2008, UT Southwestern announced plans to open the BioCenter at Southwestern Medical District, a facility to commercialize university technologies and attract biotech companies to the area. 
Also in 2008, UT Southwestern acquired the Exchange Park site and renamed it the Paul M. Bass Administrative and Clinical Center on the North Campus. The center was named in honor of Mr. Bass, chairman emeritus of the Southwestern Medical Foundation, who served in that role until 2008. With this property, the campus grew to 9 million square feet of laboratory, clinical, educational, and administrative space, covering 387 acres.
In 2009, the $186 million Biomedical Research Building (NL Building on the North Campus) opened. The building is the largest LEED (Leadership in Energy and Environmental Design) silver-certified laboratory space in Texas.
UT Southwestern opened its William P. Clements Jr. University Hospital on Dec. 6, 2014, along with the decommissioning of the 50-year-old St. Paul University Hospital. 
UTSW opened its Radiation Oncology center in 2017. 
- Parkland Memorial Hospital – The primary teaching institution of UT Southwestern, whose faculty is responsible for caring for the hospital's patients, this 2.1 million-square-foot acute care facility has 882 single-patient rooms, and more than 1 million patient visits each year.
- Children's Medical Center Dallas – The primary pediatric teaching hospital for UT Southwestern, this hospital is licensed for 490 beds, has more than 50 pediatric specialty programs, and is the only pediatric hospital in North Texas with a designated Level 1 trauma center.
- William P. Clements Jr. University Hospital – Opened in December 2014 as UT Southwestern's signature 12-floor, 640-bed hospital. Its 1.3 million square feet includes 72 adult ICU rooms, 40 emergency treatment rooms, 30 neonatal ICU rooms, 16 labor and delivery rooms, 24 surgical suites, 12 interventional suites, six endoscopy suites, six X-ray suites, four CT scans, three obstetrics specialty surgical suites, two MRIs, and two nuclear medicine rooms. The Zale Lipshy Pavilion – William P. Clements Jr. University Hospital is a 148-bed neurological treatment center and a Joint Commission-certified advanced comprehensive stroke center of the hospital.
- Dallas Veteran Affairs Medical Center – The U.S. Department of Veterans Affairs’ second largest health care system, it serves 38 Texas counties and two counties in southern Oklahoma, providing primary, tertiary, and long-term care. The 822-bed system has a Spinal Cord Injury Center, Domiciliary Care Program, and Community Living Center with a dedicated hospice unit.
- Texas Health Presbyterian Hospital Dallas – Part of the Texas Health Resources (THR) system, this 888-bed, acute-care facility was the first hospital in Dallas to receive Cycle IV Chest Pain accreditation from the Society of Cardiovascular Patient Care, and it is also accredited for emergency stroke care by The Joint Commission. In 2016, UT Southwestern and THR launched a clinically integrated health care network, Southwestern Health Resources to provide increased access to primary and specialized care to North Texas residents, from preventive measures to advanced interventions.
- Richardson Regional Medical Center
- Texas Scottish Rite Hospital for Children
- John Peter Smith Hospital of Fort Worth
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Annual patient visits to the Medical Center's clinics average 400,000 a year, up from 50,000 annually 15 years ago. This includes affiliated patient care facilities such as the UT Southwestern University Hospitals.
UT Southwestern is an Advanced Comprehensive Stroke Center, the highest level of certification. It is the only Joint Commission-certified Advanced Comprehensive Stroke Center in North Texas, one of only three in Texas .
UT Southwestern is home to an NIH Alzheimer's Disease Center and is a Network of Excellence in Neuroscience Clinical Trials Center.
The Doris and Harry W. Bass Jr. Clinical Center for Heart, Lung, and Vascular Disease is a collaborative effort between UT Southwestern faculty and community physicians.
The Center's transplantation programs for heart, lung, kidney, and liver have been certified by the federal government's Centers for Medicare & Medicaid Services.
UT Southwestern is governed by the UT System Board of Regents. The Medical Center includes three degree-granting institutions/schools: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences, and UT Southwestern School of Health Professions. Throughout its history, UT Southwestern has graduated approximately 20,000 physicians and other professionals in all areas of medicine. In 2016 alone, UTSW faculty is training about 3,700 medical, graduate, and health professions students, residents, and postdoctoral fellows.
UT Southwestern admits approximately 230 students each year. The average MCAT score is 515, and undergraduate GPA in 2017 was 3.81. The acceptance rate for 2014 was 5.6%.
UTSW is one of the five least-expensive public medical schools and among the top 10 largest medical schools in the United States. The school's tuition and fees are approximately $20,000 per year for in-state residents, being subsidized by the state. Admission is competitive and, by mandate of the state legislature, 90 percent of applicants admitted are from the state of Texas. Many out-of-state students earn competitive scholarships that make up the difference.
The Medical School's curriculum emphasizes clinical experience and electives from the first year on. The curriculum comprises three periods – Pre-Clerkship, Clerkship, and Post-Clerkship – and focuses on providing a foundation in biomedical sciences, training in clinical care, and opportunities for research.
The Medical School features six Academic Colleges that function as small learning communities, each headed by a faculty mentor.
Many students use their free time to participate in a variety of community service activities, such as United to Serve, an annual health and fun fair hosted by UT Southwestern for the surrounding community, and the weekly Monday Clinic (one of six clinics), organized by student volunteers and staffed by UT Southwestern physicians, providing free medical care to underserved Dallas communities. Other service opportunities include participating at Camp Sweeney, a summer camp in North Texas for children with diabetes.
Along with the M.D. degree, UT Southwestern offers options for students to pursue combined degrees and to earn special graduation distinctions. The combined degrees include:
- M.D./Ph.D. – Called the Medical Scientist Training Program (MSTP), this is one of fewer than 50 M.D./Ph.D.-granting programs nationwide that receive financial support from the National Institutes of Health. It combines dissertation work in an area of biomedical science, leading to the Ph.D., along with clinical studies, leading to the M.D.
- M.D./M.B.A. – This five-year program in conjunction with UT Dallas focuses on giving future physicians the skills for integrating medicine and business.
- M.D./M.P.H. – UT Southwestern and UTHealth School of Public Health in Houston offer students a degree in each field at the end of their four-year M.D. program.
- M.D./M.S. in Clinical Science – This program combines didactic training with a mentored clinical research project. The program concludes with submission and defense of a master's thesis.
UT Southwestern is ranked 25th in Research and 8th in Primary Care according to the 2017 U.S. News & World Report Medical School rankings.
With an enrollment of more than 1,000 students (467 predoctoral and 564 postdoctoral), the Graduate School educates biomedical scientists, engineers, clinical researchers, and counselors. Programs lead to Doctor of Philosophy and Master of Science degrees and, in some cases, non-degree certificates.
The Graduate School has 12 Ph.D. programs: Biological Chemistry; Biomedical Engineering; Cancer Biology; Cell and Molecular Biology; Clinical Psychology; Genetics, Development, and Disease; Immunology; Integrative Biology; Molecular Biophysics; Molecular Microbiology; Neuroscience; and Organic Chemistry.
In addition, a master's degree and a certificate are offered in Clinical Science. Postdoctoral certificates are offered in Research, Advanced Research, Cancer, Educational Techniques, Obesity and Metabolism, and Scientific Management.
UT Southwestern runs a Medical Scientist Training Program (MSTP) offering a combined M.D./Ph.D. degree. It is one of fewer than 50 M.D./Ph.D.-granting programs nationwide that receive financial support from the National Institutes of Health. The largest source of private support for UTSW's program has been from H. Ross Perot. 
The clinical training curriculum includes coursework in the disciplines necessary to understand human disease at the level of cellular physiology and biochemistry. In addition, students practice clinical skills at UT Southwestern's affiliated clinical training hospitals, including Parkland Memorial Hospital and William P. Clements Jr. University Hospital.
Following summer laboratory rotations, students choose one of 10 interdepartmental graduate programs and select a dissertation mentor from the UT Southwestern Graduate School faculty for training in intellectual and experimental strategies. During these years, the MSTP student functions as a graduate student in his or her laboratory while maintaining an awareness of clinical medicine through program activities.
Dissertation research culminates in results that significantly advance the state of biomedical knowledge.
About 340 students are enrolled in UT Southwestern's School of Health Professions. The school confers a doctoral professional degree in Physical Therapy and master's degrees in Clinical Nutrition, Physician Assistant Studies, Prosthetics-Orthotics, and Rehabilitation Counseling. The school also has a baccalaureate certificate program in Radiation Therapy.
The Physician Assistant program was founded in 1972. For the past five years, graduates have had a 100 percent first-time pass rate on the national certifying exam. Much of the training occurs at Parkland Hospital. 
|Academic Ranking of World Universities (ARWU):|
|- Overall (global)||2020||48|||
|- Biological Sciences (global)||2020||12|||
|- Clinical Medicine (global)||2020||26|||
|- Human Biological Sciences (global)||2020||8|||
|- Pharmaceutical Sciences (global)||2020||28|||
|U.S. News & World Report (USNWR):|
|- Medicine: Primary Care (national)||2021||26|||
|- Medicine: Research (national)||2021||26|||
|- Physician Assistant (national)||2019||7|||
|- Biology & Biochemistry (global)||2020||47|||
|- Molecular Biology & Genetics (global)||2020||23|||
|- Cardiac and Cardiovascular Systems (global)||2020||25|||
|- Cell biology (global)||2020||13|||
|- Endocrinology (global)||2020||12|||
|- Top 200 academic institutions in biomedical sciences (global)||2019||19|||
|- Top 200 healthcare institutions in biomedical sciences (global)||2019||1|||
|- Top 200 institutions in biomedical sciences (global)||2019||22|||
|- Top 200 institutions in cancer research (global)||2020||13|||
|- Top 200 academic institutions in cancer research (global)||2020||10|||
|- Top 100 healthcare institutions in cancer research (global)||2020||4|||
|Center for World University Rankings:|
|- Overall (global)||2020||53|||
|- Urology and Nephrology (global)||2018||5|||
|QS World University Rankings:|
|- Anatomy & Physiology (global)||2020||32|||
|- Life Sciences (global)||2020||73|||
|- Medicine (global)||2020||51-100|||
|- Biological Sciences (global)||2020||51-100|||
The Health Sciences Digital Library and Learning Center supports the information needs of UT Southwestern's research, educational, and clinical activities. The Library and Learning Center maintains a large collection of electronic information resources, print archives, rare books, and materials concerning the history of medicine. It also offers assistance and training in using these resources. The library also has a small branch on the North Campus. 
UT Southwestern had a total research expenditure of $454.9 million in 2018 of which $204.5 million was federally sourced.  UT Southwestern scientists and physician researchers conduct investigations into cancer, stem cells, neuroscience, heart disease and stroke, arthritis, diabetes, and many other fields.
At the Peter O’Donnell Jr. Brain Institute on campus, investigators research the basic molecular workings of the brain, and their application to the prevention and treatment of brain diseases and injuries. The Institute covers neurodegenerative diseases; depression and psychiatric disorders; migraines; and spine, nerve, and muscle diseases. Also at the Institute are voice specialists, rehabilitation experts, and neuroimmunologists, plus basic and translational scientists in cellular and molecular neuroscience, neurobiology, regenerative medicine, neuro-engineering, imaging, and genetics. 
Researchers at UTSW's Harold C. Simmons Comprehensive Cancer Center – the only cancer center in North Texas with the National Cancer Institute's "comprehensive" designation – are focusing on discovering drug-like chemicals that drive or inhibit cancer growth ,and deciphering mechanisms in cell regulatory networks that go awry and contribute to cancer initiation and growth. Researchers in developmental biology, cancer biology, and stem cell biology work on how developmental processes contribute to cancer's progress.
In 2011, the Children's Medical Center Research Institute at UT Southwestern (CRI) was established as a joint venture between Children's Health System of Texas and UTSW.  Located on the UTSW campus, CRI is home to an interdisciplinary group of scientists and physicians pursuing research in regenerative medicine, cancer biology and metabolism.
UT Southwestern established the Hamon Center for Regenerative Science and Medicine in 2014 for research on fundamental mechanisms of tissue formation and repair ,and to develop transformative strategies and medications for tissue regeneration.
Research at UTSW's Texas Institute for Brain Injury and Repair focuses on brain injuries and conditions, including traumatic brain injury (TBI), stroke, and Alzheimer's disease. The Institute also promotes brain injury education and prevention.
Other research currently underway at UT Southwestern includes studies on:
- Aging and Alzheimer's – Steven McKnight and colleagues identified a compound (P7C3) and demonstrated that it preserves newly created brain cells and boosts learning and memory. The study has led to further investigations into the mechanism by which P7C3 protects cells from dying and whether the compound might have any protective effect for various neurodegenerative diseases.
- Cancer/Biomarkers – John Minna and Adi Gazdar have spent the past 30 years elucidating the genetic changes associated with the development of lung cancer. Their work seeks to discover these changes and use them as biomarkers both to detect lung cancer earlier and to develop new therapies. Their approach is advancing personalized medicine, which aims to target the unique characteristics of an individual's tumor with the best current therapies.
- Cancer/Stem Cells – A team led by Sean J. Morrison at CRI has identified the environment in which blood-forming stem cells survive and thrive within the body, an important step toward increasing the safety and effectiveness of bone marrow transplantation.
- Cardiology/Regeneration – Researchers, including Eric Olson and Hesham Sadek, have pinpointed a molecular mechanism needed to unleash the heart's ability to regenerate. They found that microRNAs – tiny strands that regulate gene expression – contribute to the heart's ability to regenerate up to one week after birth. Soon thereafter the heart loses the ability to regenerate. Identifying the heart's natural regenerative on-off switch is a critical step toward developing eventual therapies for damage suffered following a heart attack. Olson's lab has also used CRISPR/Cas9 methods to cure Duchenne muscular dystrophy in mice as a proof of principle for human gene therapy.
- Cholesterol – UT Southwestern researchers have identified nearly 30 disease-causing genes, including in 1983 the gene responsible for familial hypercholesterolemia, an inherited condition that causes extremely high levels of cholesterol and heart attacks at an early age. That discovery by Michael Brown and Joseph Goldstein contributed to the pair winning the 1985 Nobel Prize in Physiology or Medicine for their research uncovering the underlying mechanisms of cholesterol metabolism.
- Diabetes/Obesity – Philipp Scherer's discovery of adiponectin, a hormone produced by fat, has helped transform the scientific concept of fat as an inert storage depot to that of an endocrine “organ” that exerts control over multiple organs. His studies have revealed adiponectin's potent anti-diabetes effects of blocking glucose production in the liver and improving insulin sensitivity in muscle. Because adiponectin levels fall as fat levels rise, drugs that increase adiponectin may be effective in fighting diabetes and other obesity-related diseases.
- Human Genetics – Helen Hobbs and Jonathan Cohen are among the world's leading experts on the genetic factors associated with lipid disorders. Their work, for which Hobbs received the 2016 Breakthrough Prize in Life Sciences, has led to the development of a new class of cholesterol-lowering drugs – PCSK9 antibodies – for patients who do not tolerate or respond adequately to statins.
- Innate Immunity – Scientists led by Zhijian “James” Chen are exploring the mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. They are focused on investigating how a cell detects harmful or foreign threats and mounts an appropriate response to restore homeostasis. Chen was elected to the National Academy of Sciences, for work including the cytoplasmic DNA sensor cGAS and its product cGAMP, a novel cyclic dinucleotide second messenger involved in innate immune response. Bruce Beutler received the 2011 Nobel Prize in Physiology or Medicine for his discovery that the Toll-like receptor 4 (TLR4) is the membrane-spanning component of the mammalian lipopolysaccharide receptor complex that senses microbial infection and triggers septic shock. Beutler continues to identify components of the mammalian immune system through large-scale mouse mutagenesis screens conducted in the Center for the Genetics of Host Defense, which he leads.
- Nobel Laureates affiliated with UTSW at some point in their careers 
Seven UT Southwestern alumni and/or faculty members have been awarded Nobel Prizes:
- In 1985, Michael Brown and Joseph Goldstein shared the Nobel Prize in Physiology or Medicine for their discovery of the basic mechanism of cholesterol metabolism. Goldstein is Chairman of Molecular Genetics at UT Southwestern, and Brown directs the Erik Jonsson Center for Research in Molecular Genetics and Human Disease.
- Johann Deisenhofer, Professor of Biochemistry and a Howard Hughes Medical Institute Investigator at UT Southwestern, shared the 1988 Nobel Prize in Chemistry for using X-ray crystallography to describe the structure of a protein involved in photosynthesis.
- The late Alfred Gilman shared the 1994 Nobel Prize in Physiology or Medicine for the discovery of G proteins and the role they play in the complex processes by which cells communicate with each other. Gilman, a Regental Professor Emeritus who died in December 2015, was Dean of UT Southwestern Medical School.
- Bruce Beutler, Director of the Center for the Genetics of Host Defense, shared the 2011 Nobel Prize in Physiology or Medicine with two other scientists for their immune system investigations. Dr. Beutler was honored for the discovery of receptor proteins that recognize disease-causing agents and activate innate immunity.
- Thomas C. Südhof, Adjunct Professor of Neuroscience and former Chair of the department at UT Southwestern, shared the 2013 Nobel Prize in Physiology or Medicine with two other scientists for discoveries about cellular transport systems. Südhof, now at Stanford University School of Medicine, was recognized for his pioneering work at UT Southwestern on synaptic transmission,. 
- Linda B. Buck (the 2004 laureate in Medicine) also did her doctoral work here.
Two current recipients of the Albert D. Lasker Award in Basic Medical Research
- 1979 Robert Estabrook, Ph.D. (deceased, 2013)
- 1980 Michael Brown, M.D.
- 1980 Joseph Goldstein, M.D.
- 1983 Samuel M. McCann, M.D. (deceased, 2007)
- 1983 Jean D. Wilson, M.D.
- 1984 Jonathan W. Uhr, M.D.
- 1985 Alfred G. Gilman M.D., Ph.D. (deceased, 2015)
- 1986 Roger H. Unger, M.D.
- 1992 Steven L. McKnight, Ph.D.
- 1993 David Garbers, Ph.D. (deceased, 2006)
- 1994 Ellen S. Vitetta, Ph.D.
- 1997 Johann Deisenhofer, Ph.D.
- 2000 Eric N. Olson, Ph.D.
- 2002 Thomas C. Sudhof, M.D.
- 2003 Joseph S. Takahashi, Ph.D.
- 2003 Masashi Yanagisawa, M.D., Ph.D.
- 2006 Melanie H. Cobb, Ph.D.
- 2006 David W. Russell, Ph.D.
- 2007 Helen Hobbs, M.D.
- 2008 Bruce Beutler, M.D.
- 2008 David J. Mangelsdorf, Ph.D.
- 2011 Luis F. Parada, Ph.D.
- 2013 Beth Levine, M.D.
- 2014 Zhijian James Chen, Ph.D.
- 2015 Lora V. Hooper, Ph.D.
- 2015 Steven A. Kliewer, Ph.D.
- 1970 Bryan Williams, M.D. (deceased, 2003)
- 1974 Donald W. Seldin, M.D. (deceased, 2018)
- 1975 Ronald Estabrook, Ph.D. (deceased, 2013)
- 1979 Charles C. Sprague, M.D. (deceased, 2005)
- 1987 Michael Brown, M.D.
- 1987 Joseph Goldstein, M.D.
- 1987 Paul C. MacDonald, M.D. (deceased, 1997)
- 1989 Daniel W. Foster, M.D. (deceased, 2018)
- 1989 Alfred Gilman, M.D., Ph.D.(deceased, 2015)
- 1994 Jean D. Wilson, M.D.
- 1995 Scott M. Grundy, M.D., Ph.D.
- 1997 Ron J. Anderson, M.D. (deceased, 2014)
- 1998 Carol A. Tamminga, M.D.
- 1999 Kern Wildenthal, M.D., Ph.D
- 2001 Norman F. Gant, M.D.
- 2001 Eric N. Olson, Ph.D.
- 2004 Helen Hobbs, M.D.
- 2005 Steven L. McKnight, Ph.D.
- 2006 Ellen S. Vitetta, Ph.D.
- 2007 Luis F. Parada, Ph.D.
- 2007 Thomas C. Sudhof, M.D.
- 2008 Bruce Beutler, M.D.
- 2009 Daniel K. Podolsky, M.D. (current University President)
- 2014 Joseph S. Takahashi, Ph.D.
- 2018 Sean Morrison, Ph.D.
- 1974 Donald W. Seldin, M.D. (deceased, 2018)
- 1981 Michael Brown, M.D.
- 1981 Joseph Goldstein, M.D.
- 1982 Jean D. Wilson, M.D.
- 1987 Samuel M. McCann, M.D. (deceased, 2007)
- 1988 Alfred Gilman, M.D., Ph.D. (deceased, 2015)
- 1992 Daniel W. Foster, M.D. (deceased, 2018)
- 1992 David Garbers, Ph.D. (deceased, 2006)
- 1992 Steven L. McKnight, Ph.D.
- 1993 Jonathan W. Uhr, M.D.
- 1994 Roger H. Unger, M.D.
- 1997 Paul C. MacDonald, M.D. (deceased, 1997)
- 1998 Eric N. Olson, Ph.D.
- 2000 Joseph S. Takahashi, Ph.D.
- 2003 Ellen S. Vitetta, Ph.D.
- 2006 Helen Hobbs, M.D.
- 2007 Luis F. Parada, Ph.D.
- 2010 Thomas C. Sudhof, M.D.
- 2011 David Russell, Ph.D.
- 2013 Bruce Beutler, M.D.
- 2015 Sandra L. Schmid, Ph.D.
- 1993 David Mangelsdorf, Ph.D.
- 2000 Nick V. Grishin, Ph.D.
- 2002 Helen Hobbs, M.D.
- 2005 Zhijian James Chen, Ph.D.
- 2005 Michael K. Rosen, Ph.D.
- 2008 Lora Hooper, Ph.D.
- 2008 Youxing Jiang, Ph.D.
- 2008 Beth Levine, M.D.
- 2008 Duojia Pan, Ph.D.
- 2008 Hongtao Yu, Ph.D.
- 2009 Joseph S. Takahashi, Ph.D.
- 2011 Sean J. Morrison, Ph.D.
- 2015 Joshua T. Mendell, M.D., Ph.D.
- 2015 Kim Orth, Ph.D.
- 2018 Ralph DeBerardinis, M.D., Ph.D.
Two current recipients of the Breakthrough Prize in Life Sciences.
- James Atkins (M.D. 1967) UTSW Professor of Medicine
- Jim C. Barnett (M.D. 1949) (deceased 2013), Member of the Mississippi House of Representatives from 1992 to 2008. 
- Linda B. Buck, (Ph.D. 1980) 2004 Nobel Laureate in Physiology or Medicine for work on olfactory receptors, currently an HHMI investigator at Fred Hutchinson Cancer Research Center
- Robert Cade, (M.D. 1954) (deceased 2007) professor of medicine and nephrology at the University of Florida, formulated Gatorade.
- Daniel W. Foster, (M.D. 1955) (deceased 2018) UTSW chairman department of medicine, holder of the UTSW John Denis McGarry, Ph.D., Distinguished Chair in Diabetes and Metabolic Research
- Norman Gant (M.D.) Former UTSW Chairman Department of Obstetrics and Gynecology
- Brett Giroir, (M.D. 1986), 16th United States Assistant Secretary for Health and admiral in the United States Public Health Service Commissioned Corps.
- Joseph L. Goldstein, (M.D. 1966) currently Chairman of the Department of Molecular Genetics at UTSW. Also Regental Professor of the University of Texas and Paul J. Thomas Chair in Medicine and the Julie and Louis A. Beecherl Distinguished Chair in Biomedical Science. Goldstein and his colleague, Michael S. Brown, discovered the low-density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. Goldstein and Brown shared the Lasker Award in Basic Medical Research (1985), the Nobel Prize in Physiology or Medicine (1985), and the National Medal of Science (1988). In recent work, they discovered the SREBP family of transcription factors and showed how these membrane-bound molecules control the synthesis of cholesterol and fatty acids through a newly described process of regulated intramembrane proteolysis. For this work, they Goldstein received the Albany Medical Center Prize in Medicine and Biomedical Research (2003).
- Francisco Gonzalez Cigarroa, (M.D. 1983), president of the University of Texas Health Science Center at San Antonio, chancellor of the University of Texas System, chief of pediatric transplant surgery at the University of Texas Health Science Center at San Antonio.
- Norman M. Kaplan (M.D. 1954) UTSW Clinical Professor of Medicine, recipient American Heart Association lifetime achievement award
- Malcolm Perry, (M.D. 1955) (deceased 2009) while a surgery resident attended to John F. Kennedy at Parkland Memorial Hospital on November 22, 1963, chief of vascular surgery New York-Cornell Hospital 1978 to 1988, professor of surgery Texas Tech University, professor emeritus UTSW.
- Stuart Spitzer (M.D. 1971?), incoming Republican member of the Texas House of Representatives from District 4
- Richard Warshak, (Ph.D. 1978) clinical and research psychologist; expert in divorce, child custody, and parental alienation; served as a White House consultant on family law reform;
- Xiaodong Wang (Ph.D.), biomedical researcher, member of the National Academy of Science 2004, Shaw Prize in Life Science and Medicine 2006, Director National Institute of Biological Sciences, Beijing
- Kern Wildenthal (M.D. 1964) president of the Children's Medical Center Foundation in Dallas, President Emeritus and Professor of Medicine Emeritus UTSW, president UTSW 1986-2008.
- Jean D. Wilson (M.D. 1955), Professor of Medicine UTSW, Institute of Medicine member, co-editor Harrison's Textbook of Medicine, National Academy of Sciences member since 1983, American Academy of Arts and Sciences member since 1982.
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- "Archived copy". Archived from the original on 2011-10-09. Retrieved 2011-05-23.CS1 maint: archived copy as title ( link)
- "Geneticist receives Breakthrough Prize". UT Southwestern Newsroom.
- "UT Southwestern researcher wins Breakthrough Prize for innate immunity discovery". UT Southwestern Newsroom.
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