UPF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UW4, 2WJV, 4CEK, 4CEM
Identifiers
Aliases	UPF2, HRENT2, smg-3, UPF2 regulator of nonsense transcripts homolog (yeast), regulator of nonsense mediated mRNA decay, UPF2 regulator of nonsense mediated mRNA decay
External IDs	OMIM: 605529 MGI: 2449307 HomoloGene: 6101 GeneCards: UPF2
Gene location ( Human) Chr. Chromosome 10 (human) [1] Band 10p14 Start 11,920,022 bp [1] End 12,043,170 bp [1]
Gene location ( Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A1 Start 5,956,280 bp [2] End 6,061,514 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon internal globus pallidus sperm biceps brachii tibia deltoid muscle postcentral gyrus amniotic fluid gastrocnemius muscle Top expressed in saccule utricle urothelium motor neuron ciliary body ectoderm otic placode secondary oocyte renal corpuscle iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding telomeric DNA binding RNA binding Cellular component cytoplasm perinuclear region of cytoplasm exon-exon junction complex nucleus cytosol polysome cytoplasmic ribonucleoprotein granule Biological process liver development nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA export from nucleus animal organ regeneration Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26019 326622 Ensembl ENSG00000151461 ENSMUSG00000043241 UniProt Q9HAU5 A2AT37 RefSeq (mRNA) NM_015542 NM_080599 NM_001081132 RefSeq (protein) NP_056357 NP_542166 NP_001074601 Location (UCSC) Chr 10: 11.92 – 12.04 Mb Chr 2: 5.96 – 6.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene. ^{[5] [6] [7]}

Function

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. ^[7] UPF2 has recently been shown to alter adult behavior via alterations in hippocampal synaptic spine density and the late long-term potentiation of neurons. ^[8]

Interactions

UPF2 has been shown to interact with UPF1, ^{[5] [9] [10] [11] [12]} UPF3A ^{[9] [12]} and UPF3B. ^{[9] [12] [13] [14]}

References

Further reading