David E. Twiggs (1790–1862), US soldier during the War of 1812 and Mexican War, and a general in the Confederate States Army during the American Civil War
John Twiggs (1750–1816), leader in the Georgia Militia during the American Revolutionary War
Levi Twiggs (1793–1847), officer in the US Marine Corps during the War of 1812, the Seminole Wars and the Mexican–American War
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